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Biomedical subjects

V M Makotchenko

Publications and source records attributed to V M Makotchenko.

At least 19 recordsLinked to original sources
PubMed1995

[Correlation between HLA antigens and immune status in dust-induced lung diseases in workers of machine-building industry].

Simultaneous study of immune state and HLA-testing was conducted for 73 patients with pneumoconiosis and 52 sufferers from dust bronchitis. The HLA antigens appeared to correlate with immune disorders in those diseases. The study revealed differences in the HLA antigens causing immune changes in pneumoconiosis and dust bronchitis. Those differences corresponded to differences between the markers of propensity to those diseases. Thus, the authors assume that formation of pneumoconiosis or dust bronchitis could depend on genetically determined variants of immune disorders.

B-Lymphocytes↗
PubMed1994

[The role of adrenal cortical dysfunction in the disturbance of intestinal digestion in chronic poisoning by nitro derivatives of toluene].

Complex clinico-laboratory study of digestion in 52 patients with chronic nitrotoluol (NT) intoxication showed that at the background of functional adrenocortical insufficiency luminal digestion as well as parietal digestion and absorption of lipids deteriorated. Hypocorticoidism being secondary in chronic NT intoxication and depending on hypothalamic dysfunction, intestinal maldigestion is related to disorders of central regulation.

Adrenal Cortex Diseases↗
PubMed1993

[Lipid peroxidation and antioxidant defence in patients with pneumoconiosis and dust-induced bronchitis].

Lipids peroxidation (LP) and antioxidant defence (AD) were compared in the patients facing pneumoconiosis and dust bronchitis. The studied group included 35 patients with suspected pneumoconiosis, 75 patients facing the 1 grade of pneumoconiosis, 43 coniotuberculosis patients and 43 patients with dust bronchitis. Active LP was demonstrated, values and intensities of its stages depended on the origin and severity of disease. AD was characteristically depressed, which necessitates the antioxidant treatment of patients with pneumoconiosis and dust bronchitis.

Adult↗
PubMed1993

[Characteristics of the ambulatory care of patients with complicated forms of dust-induced bronchitis].

The efficacy of follow-up was evaluated in 83 patients facing complicated dust bronchitis of 2 and 3 grades. An active follow-up group was treated by immunopotentiators in clinic every 3-4 months so as to prevent recurrences, while the passive follow-up group received the stationary treatment only once a year. Observations within 3 years showed a great efficiency of the active follow-up combined with the antirecurrence treatment given 3-4 times a year. Immune status was stressed to improve in connection with the clinical relief.

Adjuvants, Immunologic↗
PubMed1993

[Immune reactivity in pneumoconiosis and coniotuberculosis in machine builders].

Immune status was examined in 231 patients facing pneumoconiosis and coniotuberculosis so as to observe a dependence on pneumoconiosis type (silicosis, electric welder's pneumoconiosis), severity of the process, activity of tuberculosis. Markedly changed T and B immunity, having already appeared at initial stage of the disease, were revealed. Those changes due to the tuberculosis activity were characterized by lymphocytosis, marked functional immaturity of T lymphocytes, depressed B lymphocytes count, elevated serum Ig level.

Adult↗
PubMed1993

[A long-term prospective observation of the course of dust-induced bronchitis in mechanical engineering workers].

A study of 206 machine builders in dynamics (up to 15 years) with dust-induced bronchitis showed that the disease has a tendency to advancing within the first three years, especially in those with a combination of noxious professional factors (dust, heat, hard physical work). Negative risk factors: working conditions, preceding unspecific respiratory infections, smoking.

Bronchitis↗
PubMed1992

[The HLA antigen system in patients with pneumoconiosis].

The antigenic HLA spectra, loci A, B and C, were explored in 102 patients suffering from pneumoconiosis of workers exposed to dust in machine building. Significant frequency differences were discovered in some antigens and their complexes (AI; A I B 8; Bw35 Cw4) between the patients and control group subjects (112 healthy persons). The patients with uncomplicated pneumoconiosis and coniotuberculosis manifested appreciable differences in the antigenic HLA spectra. The authors propose an algorithm of predicting risk at pneumoconiosis as well as risk at coniotuberculosis, resting on the results of the typing of the antigenic HLA spectra.

Engineering↗
PubMed1991

[Use of chlotazol as an immunomodulating agent in chronic bronchitis].

A positive immunomodulatory effect was found in chronic bronchitis patients examined immunologically before and after treatment including chlotazol. T- and B-cell immunity recovered, clinical condition of the patients improved. A combination of known antimicrobial and antiinflammatory effects with an uncovered immunomodulatory one made chlotazol a valuable modality in the treatment of chronic bronchitis associated with secondary immune deficiency.

Adjuvants, Immunologic↗
PubMed1991

[Epidemiology of pneumoconiosis and dust bronchitis in machine-building industry workers].

The article provides a study of pneumoconiosis morbidity rate in machine-building industry workers in 1967-1986. The pneumoconiosis prevalence was ranging from 3.9 to 0.8 cases per 1000 medical examinations performed. The disease's initial forms were predominantly diagnosed through considerably frequent (30%) cases of anthraco-tuberculosis. More complicated forms of dust bronchitis were studied in 1971-1988 and registered at approximately 1 case per 1000 medical examinations. A vivid trend towards pneumoconiosis morbidity decrease and respective age and duration of work indices' growth was found in the latter decade, which was explained by more persistent measures taken towards working conditions improvement.

Adult↗
PubMed1991

[The prevalence of chronic bronchitis among workers in the dust-exposed occupations of machinery building].

Mass screenings (2455 persons) evidence high incidence of chronic bronchitis among workers of dust-related professions in the machine-building industry (foundry workers, electric welders, etc.) as compared with workers not subjected to effects of the dust factor. The frequency of chronic bronchitis was effected by length of work, character of dust profession, age, smoking.

Bronchitis↗
PubMed1990

[Laser therapy in dust bronchitis].

Laser therapies of 43 dust bronchitis patients (4 cases in 1st stage and 39 cases in 2nd stage) were performed in comparison with routine therapeutic procedures of 28 patients (6 cases in 1st stage and 22 cases in 2nd stage). 14 acupuncture points were selected. A good therapeutic effect was attained in 16.3% sample group and 7.1% control group patients, satisfactory results--in respectively 58% and 42.9% cases, insignificant results--in 25.6% and 50% cases. Along with the favourable therapeutic effect, a positive influence of laser therapy on the immune system was established, particularly on the immunity T-system, in dust bronchitis cases. Laser therapy was recommended as part of complex treatment procedures for dust bronchitis patients.

Acupuncture Points↗
PubMed1989

[Therapeutic and prophylactic measures in patients with dust-induced bronchitis complicated by pulmonary emphysema].

Therapeutic-prophylactic measures in 60 patients were directed to remove the main pathogenetic mechanisms of development of lung emphysema (control of the obstructive syndrome, normalization of the sputum rheology, reduction of the protease level, restoration of the surfactant system activity). The efficacy of complex treatment (broncholytic agents, mucus regulators, protease inhibitors, etc.) depended largely on the necessity of active prophylactic medical care of patients with dust-induced bronchitis at early stages of the disease.

Adult↗