Biomedical subjects
Publications and source records attributed to V M Miroshnikov.
The paper describes current clinical features of urological sepsis, factors provoking sepsis in urological patients, leading laboratory and clinical characteristics of the disease, principles of treatment and its results.
Blood serum levels of stage-specific antigens were measured by radioimmunoassay and immunodiffusion methods in patients with acute pyelonephritis at various stages of traditional antibacterial therapy and ultraviolet autoblood irradiation. Under study were ferritin, beta 2-microglobulin, C-reactive protein, transferrin, alpha 2-macroglobulin, and haptoglobin levels. Kinetics of the measured proteins was demonstrated and the possibility of applying their identification to assessment of treatment efficacy shown. The levels of these proteins are shown to be not only indicators of inflammation and destruction in pyelonephritis, but to reflect as well the repair reactions in the body which course most actively when UV irradiation of autoblood is added to multiple-modality treatment schemes.
Efficacy of blood UV irradiation (BUVI) followed by its reinfusion to the patient in combination with antibacterial therapy was studied in patients with acute and chronic pyelonephritis and its purulent septic complications. The BUVI was used when the antibacterial drugs failed to be sufficiently efficient and the clinical process of the infection was severe. The kinetics of ferritin, transferrin, alpha 2-macroglobulin, beta 2-microglobulin and haptoglobulin in the blood serum was investigated as a criterion of treatment efficacy. It was shown that the BUVI markedly increased the chemotherapy efficacy. The observed regularities of the changes in the serum antigenic spectrum can be used as a basis for the control of treatment efficacy.
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Processes of skin and long tubular bones' reparative regeneration under the action of serum albumin and alpha-fetoprotein on the body were studied with the use of EPR and histological methods. Relations of spin probe rotatory mobility in cell suspensions and morphological change of examined tissues are shown. It is established that the biological activity of alpha-fetoprotein is more pronounced than that of serum albumin in the effect on the young connective tissue. The stimulating effect of the embryonic protein is demonstrated only in the first week of reparative process while that of serum albumin appeared much more late.
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Experiments in 164 animals carried out by morphological, histochemical, morpho-functional and clinical methods established the fact of stimulation of the recovery processes in post-operational wounds of the stomach, urinary bladder, and radius upon parenteral inoculation of the fetal serum. The process of healing of these wounds was found to be shortened by 10-25%. The main effect of the fetal serum is directed on activation of the proliferative processes of a young connective tissue in the reparation zone. A hypothesis of the stimulating role of embryospecific proteins (alpha-fetoprotein) is suggested.
The influence of alpha-fetoprotein of man, dog and cat on the processes of reparative regeneration of the skin and long tubular bones was studied. alpha-fetoprotein was shown to stimulate regenerative processes by forming young connective tissue, but had no strong species specificity. Commercial preparation of human alpha-fetoprotein proved to possess maximum physiological activity in comparison with other alpha-fetoproteins under study.
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