PubMed Health⌕ Search

Biomedical subjects

V M Mizikov

Publications and source records attributed to V M Mizikov.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[Human factor in anesthesiology].

The authors analyze the role of "human factor" in anesthesiology as a combination of characteristics which can influence the efficiency of physician's work. Anesthesiologists should possess professional skills directly concerned with mental adaptation of personality responsible for decision making in stress or emergency. Examination of 37 anesthesiologists who had given their informed consent helped determine the psychodiagnostic criteria of professional skills and gave grounds for forming groups liable to maladaptation under high psychoemotional strain. Relationships between age, sex and professional activity were assessed. It is recommended to introduce a system of professional selection of candidates wishing to become an anesthesiologist, of individual approach to optimization of the work intensity for practicing anesthesiologists. Psychological relaxation for anesthesiologists is also essential.

Adaptation, Psychological↗
PubMedDate not supplied

[Analysis of complications and the problem of airtightness of the respiratory contour during the use of laryngeal masks in children].

Feasibility of adequate gas exchange in artificial lung ventilation (ALV) through laryngeal mask (LM) is investigated in view of high occurrence of leakage of the respiratory contour. Adequate anesthesiological techniques of LM usage are proposed. It is shown that airtightness at the site of LM cuff contact with the upper larynx is not complete. The magnitude of respiratory mixture loss in audible leakage permissible for adequate ventilation and gas exchange is estimated.

Adolescent↗
PubMedDate not supplied

[Esterase-metabolized remifentanil hydrochloride opioid (Ultiva-TM), a new step towards the solution of the problem of regulation of analgetic components of general anesthesia].

Hemodynamics, gas exchange, velocity of psychomotor recovery, pain intensity during and after laparoscopic cholecystectomy were studied in patients anesthetized (total intravenous anesthesia) by two methods: 1) remifentanyl and propofol, forced ventilation of the lungs, and myoplegia (n = 21, ASA I-III) and 2) fentanyl and propofol, forced ventilation of the lungs, and myoplegia (n = 18, ASA I-III). Total intravenous anesthesia based on remifentanyl was characterized by stability of hemodynamic and gas exchange parameters at all stages of the intervention. This method ensured a smooth and rapid course of resuscitation, characterized by absence of signs of central respiration depression, predictable normalization of psychomotor status, and low incidence of factors provoking postoperative nausea and vomiting, on condition of their prevention. Further studies of remifentanyl are needed in interventions of different degree of traumatism and within the framework of different protocols of postoperative analgesia.

Adult↗
PubMedDate not supplied

[Information stress of the anesthesiologist and intensive care specialist].

This paper discusses the results of examinations of 87 anesthesiologists and intensive care specialists, aimed at elucidation of the effects of stress factors on their work, analyzes various aspects of stress in these specialists. The resistance of a physician to psychological (information) stress is determined by biological, social, and psychological factors. The desirability of creating a universal system of psychological monitoring of anesthesiologists and intensive care specialists is validated.

Adult↗
PubMedDate not supplied

[Optimization of anesthesiological maintenance of x-ray surgical interventions in children].

Two procedures for intravenous anesthesia during X-ray surgical interventions were evaluated in 38 children aged 3 to 13 years. Initial anesthesia (with intramuscular midazole and ketamine), followed by the fractional use of the latter agents in Group 1 and propofol in Group 2, in order to maintain anesthesia. Blood pressure (BP) (noninvasively), heart rate (HR), SpO2, and respiratory rate (RR) were monitored. After the initial anesthesia, mean BP (BPmean) increased by 40 and 24% in Groups 1 and 2, respectively. So did HR by 23 and 31%, respectively. In Group these changes retained throughout the basic stage of intervention. In Group 2 on propofol infusion, BPmean and HR returned to normal values and remained at this level till the end of the intervention, SpO2 and RR did not differ from the baseline values in both groups. Thus, a combination of intravenous ketamine and intramuscular propofol provides steady-state values of BP and HR at the basic state of X-ray surgical intervention in children, which increases the reliability of studies and surgical safety in patients.

Adolescent↗
PubMedDate not supplied

[Carboxyperitoneum and clinical efficacy of nondepolarizing relaxants with different types of metabolism].

A total of 108 patients operated on the abdominal cavity were examined with laparoscopic equipment or via laparotomic assess. The recovery time of neuromuscular conduction was defined for a myorelaxant with organ-depended metabolism (pipecuronium) and, predominantly, nonorgan-depended metabolism (athracurium and cisathracurium) in relation to the type of surgical technique (laparoscopy and laparotomy). It is concluded that carboxyperitoneum prolongs the recovery of neuromuscular conduction for pipecuronium without affecting this parameter in athracurium and cisathracurium. It is more expedient to use these myorelaxants during laparoscopic operations than pipecuronium, a myorelaxant having organ-dependent metabolism.

Adult↗
PubMedDate not supplied

[Effect of carboxyperitoneum on duration of the action of some non-depolarizing muscle relaxants].

Changing pharmacokinetics of muscle relaxants with the organ-dependent metabolism (pipecuronium), which is related with the effect exerted by carboxyperitoneum on the patient-body temperature hemostasis and on the renal function are under discussion in the paper. It was demonstrated that carboxyperitoneum affects independently the decreasing body temperature and prolonged effect duration of pipecuronium. The conclusion is that the use of muscle relaxants with the prevailing organ-dependent elimination (atracurium and cysatracurium) is more preferable versus pipecuronium in laparoscopic surgery.

Adult↗
PubMedDate not supplied

[Prevention and treatment of postoperative nausea and vomiting (results of a multicenter study)].

Described in the paper are the results of a multicenter study that was conducted at 11 health-care facilities of the Russian Federation and that was based on an analysis of 623 medical records of adult patients operated on with general anesthesia of different variations. There were 154 (24.7%) males and 469 (75.3%) females, aged 16 to 90. The study denoted the need in and possibility of preventing and arresting the PONV; it also outlined those forms of ondansetron (Zofran) that can be used for the purpose, they are: parenteral and lingual pills and rectal suppositories. An assumption was put forward on the significance of PONV conductive factors and on the most effective forms of ondansetron from among the mentioned above. An understanding, resulting from the study, on that PONV is of the multietiology nature and on that its probability increases in proportion to a compatibility of provoking factors, like sex, surgery technique as well as duration of anesthesia and its variation is of importance. The efficiency of medicamental prevention of PONV by a blocker of HT3-receptors, i.e. by ondansetron (Zofran), is to a great extent predetermined by that if the form and, probably, dose of the drug is in line with a combination of the above factors, which needs further research.

Administration, Oral↗
PubMedDate not supplied

[Safety and quality of myoplegia in different types of abdominal surgeries].

The efficiency of new non-depolarized myorelaxants, i.e. of rocuronium and cisatracurium, in abdominal surgery with general anesthesia (combined or total intravenous anesthesia) of 114 patients was evaluated clinically and accelerometrically. The use of the above drugs at 2 x ED95 was confirmed to ensure a high-quality myorelaxation in different surgery variations (laparoscopy or laparotomy). A lack of effect on the hemodynamics (according to continuous non-invasive monitoring) and release of histamine (according to radioimmunology assay) make it possible to use the myorelaxants in patients with concurrent cardiovascular disease and with burdened allergic history. A bigger degree of prognosticated effect duration is typical of cisatracurium versus rocuronium, whereas the latter is a myorelaxant of choice in case a fast trachea intubation is needed.

Abdomen↗
PubMedDate not supplied

[New russian myorelaxant vero-pipecuronium (pipecuronium bromide) used for the anesthetic management of operations on the thorax and abdomen organs].

The experience of clinical use of the new Russian myorelaxant of the non-depolarizing action vero-pipecuronium (pipecuronium bromided) manufactured by "Veropharm" is described. Vero-pipecuronium was found to ensure splendid and good conditions for the intubation of the trachea and to maintain reliably myorelaxation. The recommended doses and availability of an antidote (prozerine) provide for a sufficiently controllable myorelaxation. Vero-pipecuronium does not virtually exert any effect on the parameters of hemodynamics and can be successfully used in patients with a high anesthetic risk including heart surgeries. Thus, Russian vero-pipecuronium has now an effective and safe myorelaxant manufactured inside the country, whose parameters are not inferior to those of pipecuronium bromide (arduan) manufactured by "Gedeon Richter", Hungary. Since the described drug is made in Russia, one can hope it will be highly effective both economically and pharmacologically.

Abdomen↗
PubMedDate not supplied

[Pharmacoeconomic assessment of prevention of the postoperative nausea and vomiting syndrome in plastic (esthetic and reconstructive) surgery].

A comparative "cost-efficiency" pharmacoeconomic analysis was made for 5 different anti-emitting drugs, i.e. for "Navoban", "Zofran" (intravenous administration, 8 mg; and suppositories, 16 mg) and for "Metipred" (methylprednisolone) used in aesthetic and reconstructive surgeries of 86 patients. All the drugs were found to be effective for the prevention of PONV. Clinically, the efficiency decreased in the following order: "Novoban" and "Zofran" suppositories 16 mg, "Metiored" and "Zofran" intravenous administration 8 mg. As for "cost-efficiency", preference should be given to "Metipred".

Adult↗