Biomedical subjects
Publications and source records attributed to V M Mzokova.
The article describes a case of benign meningoencephalitis attended by marked eosinophilia. The disease was evaluated as a meningoencephalitic form of Loeffler's syndrome. Drug-induced allergy is considered as a possible cause of the disease.
Immune complexes in the blood serum were determined in patients with disseminated sclerosis and in dogs in the process of experimental allergic encephalomyelitis. In disseminated sclerosis the existence of immune complexes was found in the exacerbation period and their absence in remissions. In animals with clinical signs of experimental allergic encephalomyelitis the immune complexes began to be established in the period of sensitization and attained the maximum in the preparalytic and paralytic period. In animals without clinical signs, the immune complexes were determined later and in insignificant amounts. The role of immune complexes in the pathogenesis of exacerbations in disseminated sclerosis and development of experimental allergic encephalomyelitis as factors involved in the disturbances of permeability in the hematoencephalic barrier is discussed.
Explore the source record for details and available documents.
Sixty-nine patients with multiple sclerosis from 12 to 53 years of age were examined. The titre of measles antibody in the blood serum (geometric mean) was 9.0 log2 in the patients and 5.1 log2 in normal subjects of the control group. The antibody titre was found to depend upon the stage of the disease: the sera collected in the period of remission had a titre of 7.3 log2, and those collected in the exacerbation stage 10.7 log2. Nineteen patients were examined both during remission and at the time of exacerbation: their antibody titres were 6.8 and 10.7 log2, respectively. The antibody titre did not depend upon duration of the disease, sex or age of the patients. Antibody in the cerebrospinal fluid was detected in 3 out of 8 patients in the stage of remission and in 6 out of 9 patients in the stage of exacerbation. In 4 out of 11 patients, measles immunoglobulins of the M class were found by means of serum fractionation in sucrose density gradient.