[Positive and inhibitory conditioned reflexes in experimental actions on the apical dendrites of the pyramidal neurons in the cerebral cortex].
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Biomedical subjects
Publications and source records attributed to V M Serdiuchenko.
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A phemenological model of variations in evoked potentials during conditioning is proposed. The model consists of four linear differentional equations. Variations in a wide range of only one parameter of the system of differential equations correspond to all variations in evoked potentials. A variation of this parameter in the presence of constant disturbances at the system input gives rise to the appearance of a constant or increasing signal at the output of the system, which is characteristic for the expectancy wave.
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Specialized (according to Pavlov) instrumental alimentary conditioned reflexes (CR) were studied after extremely prolonged training (2500-3000 pairings). It was established that these CR were characterized by extremely rapid extinction (till 15-20 absences of instrumental reaction after only 2-7 presentations of non-reinforced conditioned stimulus, despite the classical statement on difficult extinction of consolidated CR) independently of typological features and level of alimentary motivation of animals. The results obtained allow us to set aside such reflexes as a special category of CR which are underlined by neurophysiological and neurochemical mechanisms distinct from those of commonly used in experimental practice less trained CR. The phenomenon described may be interesting in studying the processes of learning and long-term memory.
In the course of formation of a food-procuring conditioned reflex to low-frequency electrical stimulation of the cat LGB, the corresponding evoked potentials underwent a change: the main negative component of the evoked potential in the visual area of the cerebral cortex increased; a distinct evoked potential not recorded before conditioning appeared in the sensorimotor area. The changes are regarded as EEG-correlates of formation of a forward conditioned connection. In tests with an isolated presentation of the reinforcing stimulus, a 6--8 c/s rhythm was recorded in the visual cortical area, similar to that of conditioned stimulation of LGB and considered as an EEG-correlate of a backward conditioned connection.
Neuronal activity of the visual cortex was studied in unrestrained cats with a stable food-procuring conditioned reflex to electrical stimulation of the lateral geniculate body (LGB), and in tests with presentation of a feeding trough to detect neuronal signs of backward conditioned connections. Two types of responses of the visual cortex neurones were established during manifestation of a forward conditioned connection: conditioned-inhibitory and conditioned-activating responses. Extinction of the conditioned reflex destroyed the neuronal pattern formed in the visual cortex; this correlated with the behavioral reflex extinction. It has been shown that neuronal signs of the backward conditioned connection are similar to the neuronal responses in the examined cortical areas corresponding to the forward conditioned connection.