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Biomedical subjects

V M Sukharev

Publications and source records attributed to V M Sukharev.

18 recordsLinked to original sources
PubMed1989

[Clinically conditional variants of the immune response in viral hepatitis A and B in children].

The immunity characteristics of the T-, B- and A-systems have been studied on the basis of the data registered in the dynamics of the acute period of the disease and several times in catamnesis during 6-12 months of the convalescence period in 217 children with viral hepatitis A and 99 children with viral hepatitis B. The clinical course of viral hepatitis A and that of viral hepatitis B have been found to have certain parallels in their development, as well as specific features of immune response, which can be subdivided into 3 main groups: (a) immunological imbalance, (b) the phase of immunodepression and (c) secondary immunodeficiency. The distinguishing of the variants of immune response and their clinical interpretation are of practical importance for the early prognostication of the course and outcome of the processes and for the differentiated approach to the treatment of viral hepatitides in children.

Adolescent↗
PubMed1989

[Cortisol level and immunosuppression in viral hepatitis B in children and the approach to its treatment with glucocorticoids].

As many as 132 children with verified virus hepatitis were examined. Cortisol content in blood serum was measured and the parameters of cellular-humoral immunity were determined over time in the acute period and in the catamnesis up to 1 year. In the cyclic self-limiting forms of hepatitis B, the children developed immunologic unbalance with progressive hypercortisolemia, being an adequate reaction of the stressor systems and not requiring prednisolone administration. In protracted and chronic persistent hepatitis, the children developed immunosuppression and monotonous hypercortisolemia requiring short-term prednisolone treatment. The children afflicted with the grave and malignant forms of hepatitis B demonstrated, within the early times of the disease, secondary immunodeficiency and a considerable drop of cortisol content, demanding early prednisolone administration.

Adolescent↗