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Biomedical subjects

V M Trofimov

Publications and source records attributed to V M Trofimov.

At least 19 recordsLinked to original sources
PubMed1997

[Pheochromocytoma].

Explore the source record for details and available documents.

Adrenal Gland Neoplasms↗
PubMed1995

[Postvagotomy diarrhea].

Main pathogenic factors of postvagotomy diarrhea are considered. Among them are: rapid emptying of the stomach due to the draining operation and accelerated passage of chyme along the small intestine, development of a relative insufficiency of digestion and absorption, entrance of the hyperosmolar content into the colon. Diarrhea appears more often after truncal vagotomy, is paroxysmal, then in time regresses and is successfully treated with benzohexamethonium and diet. Surgical correction as the inversion of the segment of the small intestine or restoration of the pyloric sphincter is required in single cases with critical continuously recurring form of diarrhea.

Animals↗
PubMed1991

[Evaluation of the results of surgical treatment of uncomplicated duodenal ulcers based on 10=year follow-up].

As shown by a 10-year follow-up of 187 patients operated on for uncomplicated duodenal ulcer, recurrent disease develops in 28.4% and 1.1% of cases following vagotomy and gastric resection, respectively. Positive response (group I and II according to Visick's scale) was reported in 48.9% of those subjected to gastric resection and in 45.3% of postvagotomy subjects. Possibilities of surgical management of uncomplicated duodenal ulcer require further research with due emphasis on detection of patients with relevant contraindications.

Adult↗
PubMed1990

Aldosterone content in plasma, erythrocytes and skeletal muscles in Icenko-Cushing's syndrome.

Aldosterone concentration was measured in plasma, erythrocytes and skeletal muscles in 34 patients with Icenko-Cushing's syndrome (ICS). It was established that aldosterone levels in the erythrocytes and whole blood of these patients were elevated, while aldosterone content in the plasma and muscular tissue of the patients was normal. Only in a small group of patients (N = 4) aldosterone levels positively correlated with arterial pressure (BP) and central hemodynamic parameters. Following 10 minutes of headdown tilt (-15 degrees), erythrocyte aldosterone level in the group of healthy controls (N = 12) was markedly elevated, but not in the group of patients with ICS. The results of the study suggest that erythrocytes can be viewed as a mobile aldosterone "depot" and may operate to mediate depressor effects of certain hormones on central hemodynamics.

Aldosterone↗
PubMed1990

[Evaluation of the effectiveness of vagotomy in uncomplicated duodenal ulcer based on its results 10 years after the operation].

Under analysis are results of vagotomy performed in 95 patients with uncomplicated ulcer of the duodenum after ineffective conservative treatment 10 years after operation. During this time recurrent ulcer developed in 26 patients (27.4%). The disease reappeared more frequently in patients with high level of night gastric secretion before surgery. Results of the operation in 25 patients (26.3%) could be estimated only as satisfactory because of various disorders (dumping-syndrome, diarrhea, gastric dyspepsia). But a usual basis for such an assessment was not a medial degree of some disorders (2 patients) but a combination of light degree disorders (23 patients). One patient was included into the IVth Wisik's group due to severe dyspepsia. Only 43 patients (45.3%) were included in the I and II groups by the Wisik's scheme. Results of vagotomy in patients who had no ulcer complications before operation were compared with the efficiency of vagotomy used totally for all indications and were found to be much worse. The authors make a conclusion that it is not expedient to widen indications to vagotomy at the expense of patients with uncomplicated ulcers.

Contraindications↗
PubMed1990

[The characteristics of the morphological changes in the gastric mucosa in duodenal peptic ulcer, ulcer recurrence after vagotomy and in the Zollinger-Ellison syndrome].

Results of morphometry and count of certain kinds of endocrinocytes of gastric mucosa are analyzed. Pronounced proliferative alterations of the gastric mucosa were found with clear signs of the increased function of the structures responsible for acid gastric secretion. In part of the patients with ulcer disease of the duodenum there are considerable changes in the amount of certain kinds of endocrinocytes of the antral portion of the stomach, which form accumulations in the form of different fields and even focal zones. Such alterations in the gastric mucosa have correlative relationships with the level of acid gastric secretion.

APUD Cells↗
PubMed1990

[Interrelation between hemodynamic parameters and the functional state of components of the endocrine system in patients with pheochromocytoma].

Ten patients with pheochromocytoma were examined before operation, 8 were examined 2-4 weeks after surgical treatment, and 30 in the long-term periods after elimination of hypercatecholaminemia. The patients with pheochromocytoma manifested activation of the renin-aldosterone system and inhibition of PGE2 secretion. In the long-term postoperative period, the level of aldosterone in the blood plasma was increased and that of PGE2 was reduced. In the patients with pheochromocytoma, the interrelation was discovered between the magnitude of arterial blood pressure and secretion of catecholamines, deoxycorticosterone, depressor prostaglandins. At different times after surgical treatment the central hemodynamics was found to be related to the level of mineralocorticoid hormones.

Adrenal Gland Neoplasms↗
PubMed1990

[Diagnosis of adrenal gland tumors].

An experience with diagnozing tumours of the adrenals in 159 patients has shown that overwhelming majority of the patients had hormonal disorders. Most important clinical signs taking place in various neoplasms of the adrenals were established. The minimum necessary volume of information is pointed out which must be obtained at each step of diagnozing.

Adenoma↗