[Quantitative evaluation of comparative resistance of various phages and viruses to monochloramine-B].
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Biomedical subjects
Publications and source records attributed to V M Tsetlin.
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Two Soviet sprayers (ABD-2600H and EOC-5) are recommended for the disinfection of the surfaces and indoor air in the curative and prophylactic facilities. A special impetus has been given to the use of chloramine aerosols that ensure higher efficacy of disinfection, reduce the aerosol consumption and the period of the presence of active chlorine in the air of the treated place.
A formula for the filling of aerosol containers has been elaborated on the basis of a mixture of hexachlorocyclohexane (HCH) gamma isomer and tetrametrin, in a ratio 3:1 with the addition of furniture varnish NC-62 to produce the film, Khladon 11/12 (5050) served as propellent. The study of the process of crystallization of the insecticides on the surface of the film has shown that the effectiveness of insecticidal varnishes is the higher, the smaller the size of the crystals and the easier they can be removed from the surface of the film. This can be achieved by including tetrametrin along with HCH gamma isomer in the formula. The testing of the insecticidal activity and toxicity of aerosols prepared according to the elaborated formula has demonstrated high insecticidal activity of the composition with respect to synanthropic cockroaches and fairly low toxicity with respect to warm-blooded animals.
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On the basis of experimental data, the authors present a group of parameters for the purpose of unification of comparative evaluation of the insecticidal effect of preparations in aerosol containers designed for combatting flying and non-flying domestic insects. The advisability of evaluation of the effect of the preparations for combatting flying insects according to the concentration of insecticides ensuring death of flies in the course of 15 min and the corresponding expenditure of the mixture has been substantiated. Preparations designed for combatting non-flying insects should be evaluated according to the coefficients of acute action, ovicidal and residual effects. To facilitate analysis and evaluation of the preparations in aerosol containers, the authors propose their classification according to the parameters of the insecticidal effect. Classification of the preparations under study according to their parameters is presented. It has been demonstrated that compositions containing pyrethroids and their mixtures with DDVP--Neofos, Neofos-2 and Pif-Paf are the most efficient.
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A study of some insecticidal properties of a new pyrethroid, permethrin, showed that it was a highly effective insecticide at contact, superior in this respect to neopinamin for German cockroaches, houseflies and bedbugs and superior to sumithrin for German cockroaches. Combinations of permethrin with neopinamin displayed synergism. The most active combination contained permethrin and neopinamin in a ratio of 9:1. This combination surpassed in insecticidal activity the most effective combination of sumithrin with neopinamin.
Insecticido-repellent mixtures sprayed on clothes, nets etc. are useful as a means of protection against attack by bloodsucking arthropods. These sprays provide repellence of insects sensitive to the repellent and kill those that are only weakly repellent sensitive. Combined formulae for aerosols including repellent DETA and the synthetic pyrethroid neopynamin ("Neorepellent-2") or sumithrin ("Sumirepellent") were proposed. The composite sprays were studied in an olfactometer fleas (X. cheopis) and under practical conditions by treating clothes with 7-15 g of mixture per 1 m2. The composite sprays gave 100% repellence for fleas and mosquitoes, 80-50% repellence for simuliids, 65-70% repellence for ceratopogonids and tabanids, 90-95% for ticks, and they killed 100% of insects having contacted treated surface. As regards Ixodes ticks, "Sumirepellent" was more effective than "Neorepellent-2" and caused irreversible paralysis. Toxicological tests showed the composite sprays to be safe in broad-scale practical use provided that measures of precaution were kept.
The examination of insecticidal properties of the new pyrethroid--sumithrin--showed this compound in contact action to be a highly effective insecticide, superior in activity to neopinamine. The intestinal action of sumithrin is less pronounced in comparison with neopinamine. Sumithrin is more selective in its effect on insects as compared with neopinamine. In the form of earosols, sumithrin and its mixtures with DDVP are less active than compositions based on neopinamine.
Systematic studies of the effectivity of aerosols of the mixtures of DDVP and pyrethroids tested on house flies revealed synergism among the mentioned substances the degree of which was determined by the composition of the mixtures. Among the formulae under study, the mixture of DDVP and neopynamin in a ratio 9 : 1 is of greatest interest.
The study of insecticidal properties of sumitrin demonstrated that in contact action it was a highly effective insecticide; in topical application LD50 for domestic flies, bedbugs and cockroaches was 0.47, 1.25 and 3.26 mug/g, respectively. Sumitrin possessed high action selectivity for insects and low toxicity for warm-blooded animals (LD50 for albino mice greater than 7500 mg/kg). In the form of aerosols sumitrin and its mixtures with DDVF were less active than compositions on the neopinamine base.
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