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Biomedical subjects

V M Vinogradov

Publications and source records attributed to V M Vinogradov.

At least 19 recordsLinked to original sources
PubMed2006

[Proton irradiation of the pituitary gland for alleviating pain in patients with disseminated prostate cancer].

Central Research Institute of Roentgeno-Radiology; Medical Academy for Further Education, St. Petersburg Stereotactic ablation of the frontal lobe of the pituitary with narrow beams of 1,000 MeV protons was performed in 80 patients to alleviate pain caused by bone metastases. Pain was aborted for a long time so that pain-relieving medication was suspended in 56 (70%) patients. The remaining patients cut down on taking analgetics: peripheral drugs were taken by 11(13.75%), non-narcotic opioids (tramal)--4 (5%), class III opioid narcotics--7 (8.75%), and morphine-type drugs--only 2. No untoward side-effects were reported.

Aged↗
PubMed1990

[Experience in the use of subtotal irradiation at different stages of therapy in lymphogranulomatosis].

A study was made of a possibility to use subtotal irradiation (STI) as an equivalent of chemotherapy for the treatment of 33 Hodgkin's disease patients aged 17 to 77 (of them 25 were treated during the 1st-19th yrs. of therapy, for 8 patients it was the 1st stage of antitumor therapy). ROKUS apparatus and a linear accelerator of 15 MeV were used for irradiation at a single dose of 1.5 Gy and a total dose of 3-6 Gy, at a 2-4 day interval. STI efficacy was assessed by a response of the peripheral and intrathoracic lymph nodes, tumor foci in the lungs, by a decrease in liver and spleen sizes, a decrease in body temperature and the end of night sweating. Of 25 patients a positive effect was achieved in 19, in 4 patients it was absent, and in 2 patients disease progression was observed. A marked positive effect was noted in 8 previously untreated patients, especially with respect to the elimination of signs of intoxication. A conclusion has been made that STI can be employed for the treatment of Hodgkin's disease patients as a method of general cytostatic action. STI causes a more noticeable and prolonged leukopenia than a cycle of polychemotherapy.

Adolescent↗
PubMed1987

[Total fractionated irradiation of the lymph nodes in stage III Hodgkin's disease].

The aim of the study was a comparative analysis of the results of radiotherapy of 100 patients with stage III Hodgkin's disease: 54 patients--after a split course and 46 using routine methods. A possibility of the clinical use of the split irradiation methods for therapy of patients with stage III Hodgkin's disease was shown. A stable tendency to improving therapeutic results assessed by the survival criteria was noted. The use of split irradiation reduced a period of radiotherapy as compared to routine methods.

Female↗
PubMed1980

[Effect of neuropeptide fragments of adrenocorticotropic hormone and vasopressin on the behavioral activity of rats].

The effects of vasopressin and those of fragments of adrenocorticotropin ACTH5-10; ACTH4-7; l-phenilalanin, and ACTH4-7 d-phenilalanin on the learning of rats in U-shaped labyrinth were studied. The consolidation of skills in long-term memory ability for reversal learning were checked. The results suggest that effect of all these oligopeptides on the higher nervous activity is significant and specific, vasopressin improving the long-term memory, ACTH4-7-l-phenilalanin improving the learning, ACTH4-7-d-phenilalanin making learning next to impossible.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Action of gutimine on the redox status of flavin and pyridine nucleotides in intact neurons].

Redox-reactions of flavine (FN) and pyridine (PN) nucleotides of the cell to guthimine were studied by the method of fluorescent microscopy without using any stains. The comparison was made of the kinetics of fluorescence intensity of FN and PN of the Retzius intact neuron under the action of guthimine, oxaloacetate, nembutal and succinate. It is suggested that guthimine may activate the switching of oxidative metabolism of the cell over to a more energitically profitable way.

Animals↗