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V Martić

Publications and source records attributed to V Martić.

7 recordsLinked to original sources
PubMedDate not supplied

[Motor neuron disease: primary lateral sclerosis and amyotrophic lateral sclerosis].

AIM: Primary lateral sclerosis and amyotrophic lateral sclerosis are amongst motor neuron diseases. Differences between these two disorders are stressed by this paper. SOURCE OF DATA: Articles pertinent to this subject from the past 10 years. CONCLUSION: Both disorders are of neurodegenerative pathogenesis, and motor neurons are selectively involved. Unless only motor neurons from central nervous system are involved in primary lateral sclerosis, in amyotrophic lateral sclerosis motor neurons are involved both in central and in peripheral nervous system. Clinical neurophysiological and radiological features are helpful in differential diagnosis of these diseases. Primary lateral sclerosis has better prognosis and much higher survival rate.

Amyotrophic Lateral Sclerosis↗
PubMedDate not supplied

[Modern approach to the diagnosis and therapy of myasthenia gravis].

Only two decades ago myasthenia gravis (MG) has been considered to be a severe neuromuscular disease with a very high mortality rate. Contemporary diagnostic and therapeutic approach resulted in standardized methodology for clinical management of myasthenia gravis. As an example, we present a case of generalized MG in a 22-year-old female patient. The diagnosis was based on the results of characteristic clinical, pharmacologic and electrophysiologic tests. Preoperative treatment with anticholinesterase drugs, thymectomy and postoperative course of the disease are presented. The importance of the thymus pathology and immunological serum abnormalities is emphasized. The results of this kind of clinical approach are compared with the published experience of other neurological groups.

Adult↗
PubMedDate not supplied

[The effect of therapeutic plasma exchange on serum immunoglobulins and the clinical course of myasthenia gravis].

Fourteen patients with clinically, pharmacologically and electrophysiologically confirmed myasthenia gravis in which therapeutic plasma exchange was performed were analyzed. Condition of these patients was assessed before and after the plasma exchange using the Besinger score. The serum immunoglobulin levels were also determined by ELISA-test before and after the plasma exchange. Findings have shown that clinical improvement was highly significant. Changes in IgM and IgA levels were significant, but not in IG and IgE. Significant correlation neither between the level of each separate immunoglobulin and clinical condition of the patient, nor between the change in the level of each separate immunoglobulin and changed clinical course was found after the series of plasma exchange. Cumulative effect of all immunoglobulins was not observed due to differences in their physical and chemical properties. Absence of significant statistical correlation between the level of each immunoglobulin and clinical condition of the patient as well as between the level changes of each separate immunoglobulin and changed clinical condition after series of plasma exchange could be explained by cumulative effect of all immunoglobulins, but probably also by the presence of some other, circulating factor not belonging to the class of immunoglobulins and associated with the development of myasthenic weakness.

Adult↗