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Biomedical subjects

V Massari

Publications and source records attributed to V Massari.

29 records · Page 2Linked to original sources
PubMed1989

Electrophysiologic evaluation of intravenous nicardipine in man.

The acute electrophysiological effects of intravenous nicardipine (0.014 mg/kg per min for 5 minutes) were studied in 12 subjects with estimated normal sinus node functions and atrioventricular conduction parameters. The most important effects were sinus cycle length shortening, increase of corrected sinus node recovery time and reduction of effective and functional refractory period of the atrioventricular node. Sinuatrial conduction time, atrial refractory periods, intranodal conduction, bundle branch refractoriness and ventricular refractoriness were unchanged. Systolic and diastolic blood pressure was reduced. The clinical implications of these properties of the drug are discussed and compared with those of verapamil, diltiazem and nifedipine.

Blood Pressure↗
PubMed1989

Programmed stimulation in patients with minor forms of right ventricular dysplasia.

Programmed electrical stimulation (PES) was performed in 17 patients, mean age 31 +/- 8 years, with minor forms of right ventricular dysplasia diagnosed because of (1) premature ventricular beats (PVBs) of left bundle branch block (LBBB) morphology; (2) no clinical or non-invasive evidence of cardiac abnormalities; (3) angiographic evidence of right ventricular wall motion abnormalities and bioptic findings of fibro-adipose infiltration. Fifteen patients had frequent and complex PVBs while two had sustained ventricular tachycardia (VT). During PES, sustained VT was induced in 2/2 patients with spontaneous sustained VT; ventricular repetitive responses were induced in 2/15 cases (13%) with complex and frequent PVBs. In conclusion, in minor forms of right ventricular dysplasia, PES induces VT only in patients with clinical VT; on the contrary, in patients with PVBs it is only possible to induce repetitive ventricular responses in a small proportion of cases; it is therefore not possible to select patients at high risk of developing severe ventricular arrhythmias.

Adult↗
PubMed1989

Blood donation and HIV infection: impact of seroconversion delay on the sensitivity of the testing procedure.

This study estimates the impact of the delay of seroconversion on the global sensitivity of the testing procedure among regular blood donors who give 80% of blood donations in France and in the USA. When applied to the 1987 French data, an estimate of 77 to 161 false negative donations, depending on the assumption concerning the mean seroconversion delay, was obtained, as compared to the 388 positive donations detected. The global sensitivity of the testing procedure ranged from 70 to 83%. When applied to the 1986-87 American data, an estimate of 192 to 432 false negative donations was obtained, as compared to the 1728 positive donations detected. The global sensitivity of the testing procedure ranged from 80 to 90%. These results emphasize the need to recruit blood donors in low risk subgroup populations and to develop more sensitive biological tests.

Blood↗
PubMed1988

Attitudes towards HIV-antibody testing among general practitioners and their patients.

A study was conducted by the French Communicable Diseases Network to evaluate the use of HIV-antibody testing by general practitioners. The study was aimed at determining the type of patient being tested and why. Data from two periods, Nov-Dec 86 and March-April 87, were compared. The percentages of subjects spontaneously asking for the test were about 50% in both studied periods. During the first period, tested patients were mainly male subjects (82%) and belonged to high risk groups (66%), whereas during the second period male subjects represented 47% and subjects belonging to high risk groups 27% of those tested. During the four months between the 2 study periods, an information campaign on AIDS was begun. During the second study period, in fact, the number of women being tested had increased, the number of patients with clinical symptoms had decreased and more patients were tested because of past or present STDs. In addition, fewer seropositive subjects were found during the second period. Only one subject with no known risk factor was found to be seropositive but she did have clinical symptoms of HIV infection.

Acquired Immunodeficiency Syndrome↗
PubMed1983

Imprecision of new criteria for the oral glucose tolerance test.

Subjects selected from a centre specializing in diabetes detection have been classified using nine different methods of diagnosis including the recent criteria of the National Diabetes Data Group and the World Health Organization. The applicability of these two new criteria have been evaluated and compared with seven other previous criteria. The agreements and discrepancies between these criteria have been assessed. Application of the new criteria result in a major redistribution of subjects with abnormal glucose tolerance into a rare category of diabetes mellitus and a large category of 'impaired glucose tolerance'. An important percentage of our population (33%) is excluded from the three clinical classes circumscribed by the criteria of the National Diabetes Data Group. Among these subjects, two-thirds correspond to the subjects named 'non-diagnostic' by these authors and one-third are not classifiable. The need to allow for all possible oral glucose tolerance test responses is emphasized.

Adult↗
PubMed1981

[Correlation between two variables in a populations truncated with regards to one of them (author's transl)].

This paper concerns the comparison of the correlation coefficients between two variables X and Y, a) for a whole population or b) in the sub-population in which X is greater than xo. We show a simple relationship between these two coefficients which depends only on the ratio between the sub-population variance and the whole populations variance. The corresponding graph is drawn. The observed differences between these two correlation coefficients can be large and must be taken into account for the interpretation of such data.

Biometry↗