Serum aluminum and continuous ambulatory peritoneal dialysis.
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Aged↗
Biomedical subjects
V Meisinger
Publications and source records attributed to V Meisinger.
[Aluminum-balance during haemodialysis (author's transl)].
Aluminium kinetics in patients with endstage renal failure and chronic intermittent haemodialysis have been studied. All patients revealed elevated predialytic serum aluminum levels. Because of a significant correlation between daily intake of aluminiumhydroxyd and serum aluminium levels it is concluded that the intestinal aluminium absorption plays an etiological role in the development of hyperaluminaemia. Plasma aluminium levels at the end of a regular dialysis procedure are significant lower compared to predialytic values. Similarly a significant decrease of aluminium concentration was observed in the plasma after passage through the dialyzer. This is due to the fact that the aluminium content of the dialysate used in our unit (0.1-0.3 mumol/l) is lower than the ultrafiltrable fraction of the plasma aluminium measured in vivo. Therefore a negative aluminium-balance during haemodialysis has to be assumed in our patients. Extreme aluminium-accummulation seems to be avoided and we therefore never experienced aluminium intoxication and dialysis dementia in our center. To assess a negative aluminium balance during haemodialysis, because of high protein binding of aluminium, a dialysate with an extreme low aluminium content has to be recommended.
Adolescent↗
[Control studies on retired lead workers].
Nine lead-workers, with an exposure time of 26 years, are investigated 10 years, after they had retired. There are no differences in the blood-count, hemoglobin, blood-lead level, urin-delta-aminolevulinic-acid, urincoproporphyrin and delta-aminolevulinic-acid-dehydratase-activity in their blood, upon comparison with a control group without lead-exposure. The mean urinary excretion of lead (0.119 mumol/g Kreatinin = 24 microgram/g Kr.) was 8 times higher than of reached by the controls (0.014 mumol/g Kr. = 2.7 microgram/g Kr.). The injection of CaNa2-EDTA increased the lead excretion to 0.197 mumol/g Kr. = 40.8 microgram/g Kr., in the control group 0.123 mumol/g Kr. - 25.7 microgram/g Kr. (62%). Therefore these two investigations are recommended for detection of previous lead exposure.
Aged↗
[Serum cobalt and serum chromium level in 2 patients with chronic renal failure after total hip prosthesis implantation with metal-metal gliding contact].
PURPOSE: The influence of chronic renal failure on serum cobalt and serum chromium in two patients with metal-on-metal bearing (Metasul) and cementless total hip arthroplasty (Alloclassic) is investigated. METHODS: Serum cobalt and serum chronium levels were determined in the postoperative course using atomic absorption spectrometry. RESULTS: Maximum values are found to be more than 100-fold elevated when compared to the reported median serum cobalt concentrations in patients with the same prosthesis type and no known renal disease. CONCLUSION: Chronic renal failure seems to be responsible for the marked elevation of serum cobalt and serum chromium. CLINICAL RELEVANCE: Despite evidence of adverse health reactions, a possible effect of long-term cobalt and chromium loading cannot be neglected. In our opinion, metal-on-metal bearings in THA should not be inserted in patients with chronic renal failure. Follow-up investigations (serum cobalt, serum chromium, serum creatinine, BUN, echocardiography) should be performed at short intervals.
Adult↗
[Concentrations of cadmium in the blood of smokers and nonsmokers not occupationally exposed to the metal].
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Adult↗
[Lead, mercury and cadmium in newborn infants and their mothers].
The objective of the present study was to determine the toxic trace element status of 51 healthy Austrian women and their newborn babies. Lead, mercury and cadmium content of early breast milk, blood and urine were measured post partum by atomic absorption spectrophotometry. None of the toxic trace elements could be found in elevated concentrations; the content of mercury and cadmium in milk was below limits of detection. Mean lead concentration in breast milk was 35.8 (SD:15.0) micrograms/l. Whole blood content of lead was 37.0 (SD:12.7) micrograms/l in mothers and 26.3 (SD:11.6) in newborns. High blood concentrations of mercury were found both in mothers (4.46 micrograms/l, SD:1.95) and in umbilical cord blood (5.58 micrograms/l, SD:2.33). The corresponding values for cadmium were 0.44 (SD:0.4) micrograms/l and 0.08 (SD:0.16) micrograms/l. Urine excretion of the elements assayed was normal. Significant correlations between maternal and neonatal blood toxic mineral levels could be demonstrated in lead (p < 0.001).
Adult↗