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Biomedical subjects

V Michael

Publications and source records attributed to V Michael.

18 recordsLinked to original sources
PubMed1999

Renal cell carcinoma in children under 14 years old: long-term survival.

OBJECTIVES: To assess the treatment and long-term survival of children under 14 years old operated upon for renal cell carcinoma (RCC). PATIENTS AND METHODS: The records of five patients (aged 2, 4, 6, 9 and 13 years) who had been treated for RCC between 1982 and 1993 were reviewed. All had undergone nephrectomy with (two) or without (three) regional lymphadenectomy. After surgery four patients received chemotherapy (vincristine with actinomycin-D, three, vinblastine, one), and two with advanced-stage disease received other agents (interferon alpha, interleukin-2). They were followed for 5 to 15 years. RESULTS: Three patients with stage I-II RCC were well at 13, 15 and 15 years after treatment. Of the two patients with regional lymph node involvement (stage III), one was well 5 years after surgery while the other developed hepatic, lung and bone metastases, and died 2 years after presentation. CONCLUSION: The prognosis and long-term survival of children under 14 years old with RCC is very good for those with low-stage tumours. Nephrectomy with complete tumour extirpation is the main mode of treatment. For advanced-stage tumours, the role of adjuvant chemotherapy and/or biological agents must be defined more clearly.

Adolescent↗
PubMed1993

Effects of submucosal Teflon paste injection in vesicoureteric reflux: results with 1- and 2-year follow-up data.

One hundred refluxing ureters with grades II (n = 65), III (n = 27) and IV (n = 8) vesicoureteric reflux (VUR) were treated with endoscopic submucosal polytetrafluoroethylene (Teflon) paste injection. Reflux stopped in 77 ureters after a single injection and in 13 ureters following a second injection. Two ureters remained with minimal (grade I) residual reflux, whilst in another 5 improvement from grades III and IV to grade II reflux was noted. In 3 ureters reflux remained unchanged, because of lateral ectopia of the refluxing ureteric ostium, hindering the injection of Teflon into the correct position. Re-evaluation at 1 year postinjection, of 48 previously cured ureters showed recurrence of reflux in 1 (2%), but no further recurrences were noted in 19 ureters reevaluated after 2 years.

Adolescent↗
PubMed1992

Identification of a haptoglobin-hemoglobin complex in the Alaskan Least Cisco (Coregonus sardinella).

The hemoglobin and a hemoglobin binding protein have been characterized in the Arctic fish (Coregonus sardinella). The evolutionary significance of the hemoglobin and plasma protein differences between fish and mammals is still unresolved. Blood samples from the Alaskan Least Cisco were separated into plasma and hemoglobin fractions and the proteins in these fractions were analyzed both by alkaline agarose gel electrophoresis, by isolelectric focusing, and by capillary electrophoresis. Staining the plasma proteins gels with o-dianisidine revealed hemoglobin containing protein complexes. A hemoglobin-containing band was observed in hemolyzed plasma which did not migrate with free hemoglobin, and is believed to be hemoglobin-haptoglobin complex. Size exclusion chromatography further characterized the hemoglobin as disassociating freely into dimers, and hemoglobin-haptoglobin complex having a molecular weight greater then 200,000 daltons.

Animals↗
PubMed1992

Urothelial tumors of the bladder.

Neoplasms originating from the transitional epithelium of the urinary bladder are rare in children. This paper examines the clinical, epidemiological and histopathological characteristics of 3 such cases. The patients were males aged 4, 8 and 14 years at the time of diagnosis. Total painless hematuria was the presenting symptom in all of them. There was no history of previous exposure to dyes or other chemicals, but 1 patient was a systematic cigarette smoker. All tumors were solitary, noninfiltrating, grade 1 neoplasms. Following their local resection, no recurrences were noted 3-8 years postoperatively. This review supports the contention that transitional cell neoplasms of the bladder are less aggressive in children and, therefore, their local management constitutes an adequate therapeutic approach.

Adolescent↗
PubMed1991

Paediatric urolithiasis in Greece.

A group of 44 patients, aged from 10 months to 14 years, underwent surgery for urinary calculi over a 7-year period (1982-1989). Eleven patients had bilateral or multiple calculi (total number of stones = 55, 20 of which were staghorn). Metabolic disorders (n = 25) and Proteus urinary infection (n = 15) were the 2 factors most often associated with lithiasis. Of the 55 stones, 51 were removed by open surgery. Complete stone clearance was achieved in 29 of 36 kidneys. Follow-up periods in the remaining 7 renal units (with small residual fragments) ranged from 3.5 to 7.5 years (mean 6.2) and revealed stone recurrence in only 2 patients. Evaluation of childhood urolithiasis should include thorough metabolic investigation and sound surgical judgment; effective management requires prolonged post-operative follow-up.

Adolescent↗
PubMed1991

Ostioplasty: a simple technique for ureterovesical reconstruction following intravesical ureterocelectomy.

A simple operation for the management of simple, i.e. intravesical, ureteroceles, which we have named 'ostioplasty', is presented. After unroofing the ureterocele, the retracted, gaping ureteric ostium is advanced and fixed medially to the center of the bladder trigone with three 5-0 polyglycolic acid sutures. The exposed intravesical ureter is covered with a new mucosal layer formed from the mobilized lateral edges of the unroofed ureterocele, sutured together over the ureter with 5-0 polyglycolic acid. Ostioplasty has been used in 5 patients so far with excellent anatomic and functional results. It is a simple and valuable surgical option to standard ureterovesical reimplantation after excision of a simple ureterocele, provided that the ureterocele is of moderate size and the bladder trigone retains good muscular support.

Adolescent↗
PubMed1990

Surgical treatment of ectopic ureteroceles and the role of heminephrectomy with subtotal ureterectomy.

We evaluated 16 patients, 2 weeks to 8 years of age (median: 18 months), operated on for ectopic ureterocele. Five patients, in whom the upper kidney, drained by the ureter with the ureterocele, was viable, were submitted to excision of the ureterocele with reimplantation of the double ureter (n = 4) or high ureteroureterostomy (n = 1). A 2-week-old baby with a non-functioning kidney was treated by nephroureterectomy. The remaining 10 children with a non-functioning upper part of a duplex kidney were submitted to heminephrectomy with subtotal ureterectomy. In this group of patients no problems arose from the retained ureteral stump or the decompressed ureterocele, and vesicoureteral reflux accompanying the ureterocele resolved postoperatively in 6 of 10 ureters.

Choristoma↗
PubMed1990

Evaluation of open surgery for staghorn calculi in children.

We evaluated the results of open surgery in 19 children with staghorn calculi. The median age was 3.5 years (range 10 months to 14 years). One patient had bilateral calculi, hence 20 renal units were operated upon. Stone clearance was achieved in 19 cases by means of a Gil-Vernet pyelocalycolithotomy, alone (n = 10) or in combination with limited radial nephrotomies (n = 9). Extended nephrolithotomy was performed in only 1 case. Complete stone clearance was achieved in 13 kidneys (65%). Long-term follow-up showed that there was no stone recurrence in any of the 13 renal units rendered completely stone free at surgery. There was symptomatic stone recurrence in 1 of the remaining 7 renal units with small residual fragments left behind, while in 2 others the residual fragments were voided spontaneously. Preoperative and postoperative assessment with 99mTc-DMSA renal scans confirmed that no functional loss resulted in any of the operated kidneys. Open surgery proved to be safe and effective in the treatment of staghorn calculi in children.

Child, Preschool↗