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V Miller

Publications and source records attributed to V Miller.

194 records · Page 11Linked to original sources
PubMedDate not supplied

Activity of cellular thymidine kinase 1 in PBMC of HIV-1-infected patients: novel therapy marker.

Cellular cytoplasmatic thymidine kinase 1 (TK1) catalyzes the intracellular phosphorylation of anti-HIV-1 nucleoside analogs zidovudine (AZT) and stavudine (d4T) to the corresponding monophosphate form. In HIV-1-infected patients, treated with combination therapy including one of these compounds for more than 1 year, enzymatic activity of TK1 in peripheral blood mononuclear cells (PBMC) was determined by radioactive assay. TK1 activity in PBMC of HIV-1-infected patients correlated with CD4 cell count (r = 0.4, p<0.05) and HIV-1 RNA copy number (r = 0.4, p<0.05), being lower in patients with decreased CD4 cell count and high viral load. Furthermore,TK1 activity differs between HIV-1-infected individuals treated for more than 6 months (13.5 pmol/mg/h) compared to patients treated for less than 6 months (28.1 pmol/mg/h; p<0.05) with chemotherapeutic agents including thymidine analogs. The results demonstrate that TK1 deficiency in PBMC of HIV-1 infected patients may develop due to continuous treatment with thymidine analogs and correlates with a more progressed stage of disease expressed as diminished CD4 cell count and increased viral load.

Adult↗
PubMedDate not supplied

Antiviral activity of tenofovir (PMPA) against nucleoside-resistant clinical HIV samples.

The presence of the lamivudine-associated M184V RT mutation increases tenofovir susceptibility in multiple HIV genotypes. Tenofovir is uniquely active against multinucleoside-resistant HIV expressing the Q151M mutation, but shows reduced susceptibility to the T69S insertion mutations. HIV with common forms of zidovudine and lamivudine resistance are susceptible to tenofovir, corroborating phase II clinical results demonstrating the activity of tenofovir DF in treatment-experienced patients.

Adenine↗
PubMedDate not supplied

[The characteristics of the removable denture treatment of the edentulous elderly].

PURPOSE: The increasing number of the elderly with in the general structure of population, has deep implications for dentistry. Age changes upon the tissues which make up the totally edentulous prosthetic field often lead to special therapeutical difficulties in the provision of a comfortable denture. MATERIALS AND METHODS: The work has at the main aim the same specific aspects met in the removable gnathoprosthetic treatment of the edentulous elderly patients (84 cases). The treatment applied took into consideration the changes occurred upon the tissues, general peculiarities of this age period but also the patients request. RESULTS: The results obtained demonstrate the problems met during the prosthetic treatment of the edentulous elderly patients to reestablish esthetic function and the possibilities of restorative. CONCLUSION: The prosthetic treatment of the elderly must have to the basis an integrative concept and not a standard one, being individualized for each particular case and every therapeutical stage must be adapted to the preestablished local and general Geroindex.

Aged↗
PubMedDate not supplied

[Computer-assisted clinical gnathoprosthetic examination].

Within the informatics strategy of the clinic of dental prosthetics we suggested, among other things, a computer-assisted clinical gnathoprosthetic examination, a careful and complete examination being the first medical act when the patient presents to a physician. The information collected during the patient's examination (essential data on affections of the stomatognathic system) were systematized in a data base. Since this data base is organized according to the methodology of a complete and complex clinical and paraclinical examination, the possibility of involuntarily omitting certain information is excluded.

Databases, Factual↗
PubMedDate not supplied

Kawasaki syndrome.

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Humans↗