[Case of hemobilia].
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Biliary Tract Diseases↗
Biomedical subjects
V Minkova
Publications and source records attributed to V Minkova.
[Cardiovascular changes among deceased patients with diabetes mellitus and diabetic nephropathy among 9015 autopsied over the age of 14].
Out of 9015 necropsies of patients, over the age of 14, performed between January 1, 1967 and March 1, 1979 at a general hospital in Sofia, 729 of them (8,07%) proved to have diabetes as well. Renal complications were found in 315 of them (43,2%)--chronic pyelonephritis being most frequent (21,2% of all diabetics) followed by diabetic glomerulosclerosis (DG)--18,5 per cent of the diabetics and in 7,9 per cent--a combination of both complications. The authors studied only the patients with DG. They lived about 5,2 years, on the average, less than the other diabetics and 91,1 per cent of them had arterial hypertension versus 61,3 per cent among the rest of the diabetics. A total of 90 per cent of the hypertonics with DG had left ventricular hypertrophy--I--III stage. Atheromatosis of aorta and coronary arteries were found, in those deceased from hypertonic disease, to be more frequent and more severely manifested, than those decreased from chronic pyelonephritis with hypertension and than those deceased from chronic glomerulonephritis with hypertension in all age groups. Regardless of that, the morbidity rate among the deceased with DG from cardiac complications is a little less than that among the deceased from hypertonic disease and the causes for brain vascular complications among diabetics, in spite of the more frequent and more severe atherogenesis has been three times less rare than among the deceased from hypertonic disease. Very likely, the involvement of the kidneys contributes to those discrepancies.
Adolescent↗
[Hypertension incidence and its reflection in vascular and organic lesions in 9014 autopsies of subjects over 14 years of age].
The authors found arterial hypertension in 1943 (21,55%) of the deceased (males 17,7% and females 26,62%) out of 9015 necropsies performed on subjects over the age of 15, for the time period January 1, 1967-February 28, 1979 at a general hospital. According to etiology 59,18 per cent of them were with essential hypertension (hypertonic disease--HD) and 40,18 percent--with renal hypertension. The average duration of hypertension in those that had died of hypertonic disease, according to anamnestic data was 15,8 years. Only 5,47 per cent of the hypertonics, died after the age of 50, whereas more than 40 per cent of them died after the age of 55, so that age type hypertension could be referred to in those cases. In 98,10 per cent of the deceased of HD, hypertrophy of left ventricle was found in 85,92 per cent, its wall being equal to or over 20 mm. Atheromatosis, stage II and higher (atherosclerotic plaques, plaques with calcium deposition and with complications--hemorrhage, thrombosis, etc) were found in 84,84 per cent of the deceased with HD, over the age of 50. The authors found an extremely high correlation relation-ship between the incidence and severity of atheromatosis of aorta, coronary and cerebral arteries and the age of the deceased of HD, but at the same time--a statistically significant difference between the incidence and severity of atheromatosis in those regions of the deceased with HD and the controls--normotonics (524 deceased). The relatively long duration of life-span of the deceased of HD--an average of 67,4 years, is attached, by the authors, to the favourable role of the present antihypertensive treatment and to a more frequent development of HD at an advanced age.
Adolescent↗
[Incidence and the degree of cardiovascular changes and causes of death in 717 patient who died of chronic pyelonephritis with and without arterial hypertension].
The authors examined 9015 necropsies, over the age of 14, in a general hospital for the period January 1, 1967 to March 1, 1979. They found that the chronic pyelonephritis (ChPN) was the most frequent renal diseases with a lethal end--62.83 per cent of the renal patients and 7.95 per cent of all deceased. In 458 (63.87%) of them ChPN was accompanied by arterial hypertension (AH), which with an average duration of 8.8 years had caused a considerable hypertrophy of left ventricle. A better manifested atheromatosis of aorta, coronary, cerebral and renal arteries, being statistically significant, was found in the deceased with ChPN and AH as compared with the control group of 524 subjects, deceased without hypertension but that atheromatosis was less manifested than in those that died of hypertonic disease. That fact was explained by the authors with the shorter duration of hypertension in ChPN, with a more strict nutritional regimen among them, with the shorter life span and azotemia, as well as with the more active involvement of adrenergic systems of the patients with ChD. Whereas in 2/3 of the deceased with ChPN, without hypertension, the cause for the lethal end was uremia and urosepsis, the incidence of cardiac and cerebral-vascular complications, in those deceased with ChPN and AH, was 6 times greater than the first and uremia and urosepsis--considerably less frequent.
Adult↗
[Stereology of the interstitial cells of the renal medulla in shock].
The authors carried out quantative stereologic studies on the electronograms of intersticial cells of the medulla of the kidney during shock. There was a considerable lowering of the number and volume of lipid granules in comparison with the control nontreated animals. The results were interpreted as a manifestation of the increased release of prostaglandins from the renomedullar intersticial cells as mediators of some local processes in the kidney, enduring shock.
Animals↗