Biomedical subjects
Publications and source records attributed to V Molinari.
Cultures of human intestinal aerobic flora did not have any inhibiting action on the immunologic reactivity of hepatitis B antigen even after disruption of bacterial cells by freezing and thawing. This suggests that the inhibitor is elaborated by the human intestinal mucosa.
During acute HBsAg serum positive viral hepatitis, the surface antigen was not detectable in duodenal bile but was almost always present in gallbladder and hepatic bile when cholecystokinin was intravenously administered. The immunologic nondemonstrability of HBsAg in duodenal bile is probably due to the presence of a factor elaborated by the intestinal mucosa. The possible role played by this factor in the non transmission of type B viral hepatitis via faecal-oral route is suggested.
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There has been limited research on the prevalence of personality disorders in the aged. No studies have documented the extent of personality disorders in community-dwelling elderly with the use of a structured scale specifically designed to detect personality disorders and anchored to DSM-III-R criteria. One hundred male and 100 female community-living elderly (mean age, 72.1 years) were administered the Structured Interview for Disorders of Personality-Revised to compare prevalence rates for specific personality disorders with those of young adults (mean age, 41.7 years) and to identify demographic variables associated with personality disorders in the elderly. Results indicate a tendency toward fewer personality disorders in older than young adults, no differences in the frequency of personality disorders between male and female elderly, and significantly more prior mental health consultations in elderly with personality disorders than in elderly without these disorders. Aging processes and methodologic issues that could account for differences in personality disorder distribution between young and older adults are discussed. Recommendations for future research are outlined.
One hundred males from a Veterans Affairs geropsychiatric inpatient ward, and 100 females from a geropsychiatric inpatient ward of a private hospital completed the Structured Interview for Disorders of Personality-Revised (SIDP-R). Chart reviews provided information including age, years of education, marital status, race, as well as Axis I and Axis II psychiatric diagnoses. Data from a young adult sample, drawn from an initial SIDP-R validation study, were used for comparison. Results indicate a 56.5% rate of personality disorders (PD) for older patients. Significantly more elderly men than elderly women were diagnosed with PD by psychiatric evaluation, and elderly men were also more likely to be diagnosed with paranoid, avoidant, and multiple PD using the SIDP-R. Psychiatrists gave far fewer Axis II diagnoses than were yielded by the SIDP-R, particularly with females. There were no significant differences in total PD rates between aged and young subjects, but older adults with PD were diagnosed less frequently with multiple PD. Older adults were also less likely to be diagnosed with the "Dramatic" cluster PD, and more likely to be diagnosed with the "Odd" cluster PD. The level of depression was related to both clinical and SIDP-R diagnoses.
The literature on life review reminiscence in the elderly is reviewed. Research indicates that life review is a personal, self-evaluative form of reminiscence with intrapersonal and interpersonal dimensions. The nature and quality of these dimensions change with age. The process and outcome of life review in the elderly may vary as a function of independent, as compared with institutional, living. There needs to be closer correspondence between clinical and research endeavors since empirical documentation is lacking regarding the efficacy of life review groups. It is suggested that an integration of intrapersonal and interpersonal approaches may provide the basis for a broad conceptualization of life review reminiscence in aged adults.
Levenson's Internal, Powerful Others, and Chance scales were administered to 305 college undergraduates and 117 community-living elderly. On the basis of their highest standard score, sixty young and sixty elderly participants were then classified into High Internal, High Powerful Others, and High Chance categories. The young sample was administered the Zung Depression Scale and the debilitating anxiety scale of the Alpert-Haber Achievement Anxiety Test, while the elderly were given the Beck Depression Inventory, the Depression and Anxiety Scales of the Profile of Mood States, and rated on the Hamilton Rating Scale for Depression. Contrary to previous results, the elderly sample was more external (on the Chance dimension) than the young. As predicted, there was a significant relationship linking a pattern of high internality and low belief in powerful others with low depression in the elderly, but not in the young. Applicability of these findings to placement and intervention strategies is discussed.