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Biomedical subjects

V Munteanu

Publications and source records attributed to V Munteanu.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[The results of the Ravitch-Sutherland technic for surgical correction in pectus excavatum].

The aim of our study was to assess the functional and cosmetic results after performing a modified Ravitch-Sutherland procedure in children presenting with excavatum. A series of 31 children with ages ranging between 5 and 16 years, presenting with pectus excavatum, were operated between 1986-1996 in our service. In 5 cases surgical treatment was required by the presence of respiratory and/or cardiac functional impairment due to the malformation. In the other 23 cases operation was performed mainly for cosmetic reasons. In all cases a modified Ravitch-Sutherland procedure was performed. Modification consisted in renouncing at the plicature of the perichondra and in associating a diaphragmatic elongation and Bedouelle laparoplasty in all cases. Longitudinal sternotomy was performed in 2 cases with severely impaired ventilatory capacity. Functional and cosmetic results were good in all cases. In 2 cases, in which recurrence of the condition was observed, a second identical procedure was performed, with a good result. The interval between the operation and the moment of long-term evaluation ranged between 3 months and 11 years. We conclude that the modified Ravitch-Sutherland procedure represents an effective method for the treatment of pectus excavatum cases, offering good functional and cosmetic long-term results.

Child↗
PubMedDate not supplied

[Achalasia in children: Diagnostic opportunities and therapeutical options].

Achalasia is a functional disorder of the distal esophagus, which fails to relax during swallowing. Although being rare, this disorder is the source of a significant morbidity, including developmental disorders in children. Several therapeutical options are available: myorelaxants administration, esophageal dilations and surgery--distal esophageal myomectomy followed by an antireflux procedure. The paper introduces our experience in treating a number of 5 children between 1991 and 1998.

Adolescent↗
PubMedDate not supplied

[Primary obstructive megaureter- diagnosis and treatment].

The authors have treated 13 cases of primary obstructive megaureter (POM) in children, presenting without vesicoureteric reflux. The diagnostic possibilities and the surgical approach options are discussed. Both Cohen and Leadbetter--Politano uretero-vesical reimplantation techniques proved to be successful in this series. Ureteric folding was done in 2 cases. Reported final results are good in 10 cases.

Adolescent↗
PubMedDate not supplied

Complications following gastric tube esophagoplasty in children.

Surgery in children with caustic esophageal burns, esophageal atresia or other esophageal disorders can be performed using gastric tube esophagoplasty. Between 1991 and 1999, a number of 41 such procedures have been performed in our department, using the original technique developed by Gavriliu. The results were assessed as good and very good in 83% of the cases, and fair or bad in the rest of 17%. We recorded 13 cases with significant complications, 4 of which ended with exitus. The paper present our experience in using gastric tube esophagoplasty and the management of the complications related to this procedure.

Adolescent↗
PubMedDate not supplied

[Indications for esophageal replacement in children].

Esophageal substitution in children is required in several types of esophageal atresia, as well as following strictures caused by caustic ingestion or peptic esophagitis. Nowadays, two main types of procedures are used for esophageal replacement: colon segment esophagoplasty (that seems to be preferred by most pediatric surgeons) and gastric tube esophagoplasty. The paper presents the personal experience in the management of a series of 56 children with esophageal replacement, during the last 10 years. In 46 patients, the stricture cause was caustic ingestion, while peptic esophagitis accounted for 3 cases. The remaining 7 cases were long-gap esophageal atresias that could not be managed by primary neonatal anastomosis. The results are rated as good in 42 cases. Complications occurred in 13 cases, while fatal outcome occurred in 5 patients. The most remarkable feature of the series is the high number of procedures required after caustic ingestion.

Adolescent↗
PubMedDate not supplied

Detection of Bacteroides fragilis group by immunofluorescence.

The following strains: B. fragilis subspecies thetaiotaomicron (A); B. fragilis subspecies fragilis strain E-1, E-2, M, St., Se., Ni., 8, 16; B. fragilis subspecies distasonis 145 (D) were serologically studied by immunofluorescence as compared to agglutination. Anti-B. fragilis sera titration by immunofluorescence (IF) reaction, as compared to agglutination reaction in tube, was more sensitive (2-16 times higher titers), specific and reproducible. Among the organisms from B. fragilis group, species, subspecies and even train specificity was noticed. Also, the possibility for rapid identification of anaerobic organisms, belonging to B. fragilis group, in pathologic products obtained from experimentally infected animals (mice and rats), by IF reaction, in comparison with classic methods (anaerobic cultures and biochemical determinations) was studied. Of 87 studied animals, 61 proved positive by cultures and 59 by IF; 56 animals were shown positive and 23 animals proved negative by both methods (intermethods concordance in 79 cases). Statistical analysis of IF results provided the following: method sensitivity (detection capacity of real-positive cases)-91.80%; method specificity (detection capacity of real-negative cases)-88.46%; false-positive cases-11.53%; false-negative cases-8.19%. Immunofluorescence proved specific, sensitive, practical and rapid method detection of non-sporulated anaerobic organisms species and subspecies belonging to Bacteroides fragilis group.

Agglutination Tests↗
PubMedDate not supplied

New data concerning the effects of 6-hydroxydopamine on the exercise performance in rats.

An injection of 250 micrograms 6-OHDA into the right cerebral ventricle of adult rats tested after 45 days led to a reduction of the run performance on the treadmill compared with the control group, but only in the first period of this test, repeated 10-11 times, every 2-3 days. This behavior was more obvious in male and in exercise-enduring rats. The histological examination proved partial destruction of central monoaminergic (especially dopaminergic) structures in the 6-OHDA treated rats. 24-48 hours after peripheral injections of 6-OHDA (100 mg/kg b. w.) a considerable reduction of the run and swim performance (acute exercise till exhaustion) occurred. Falck's histofluorescence method proved large destructions of the noradrenergic innervation in the iris; 6-OHDA injected i.p. into neonatal rats had similar effects.

Animals↗
PubMedDate not supplied

[Sensitivity to combined metronidazole and penicillin in 227 strains of non-sporulated anaerobic bacteria].

Combined metronidazol-penicillin, used in large amounts corresponding to the selective concentrations in vitro of 25 + 25 IU, may be assumed to be effective in all clinical infections in which one or several anaerobes are implicated. The experiments carried out demonstrate that this is valid for all categories of Grampositive or Gramnegative non-sporulate anaerobes. The antibiotic concentrations used are well tolerated by the human organism.

Bacteria↗