Two-dimensional discrete model for DNA dynamics: Longitudinal wave propagation and denaturation.
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Biomedical subjects
Publications and source records attributed to V Muto.
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DNA is modeled as a homogeneous, cylindrical rod with nonlinear elasticity using the Ostrovskii-Sutin equation (OSE) with periodic boundary conditions. This equation predicts that longitudinal sound waves will be concentrated into packets called solitons. From a study of the damped OSE, we conclude that decay time is almost independent of the solitonic character of the solution. For the damped, driven OSE, on the other hand, we find that spectral features (such as absorption line widths and fine structure) are strongly influenced by the presence of anharmonicity. This effect is enhanced as the length of the DNA is increased.
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Personal experience of Technetium-99m-sulfur colloid in the scintiscanning of bone marrow is reported. The method offers technical advantages over other methods and superior protection, while its only limitation is that it does not permit a dynamic study of hematopoiesis. Four pathologic scans typical of four groups of diseases may be distinguished. Further, metastatic bone marrow localisations can be diagnosed much earlier and more precisely than by radiography.
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