PubMed Health⌕ Search

Biomedical subjects

V N Dagaev

Publications and source records attributed to V N Dagaev.

At least 19 recordsLinked to original sources
PubMed1985

[Age-related aspects of intensive therapy of acute poisoning of chemical etiology].

Assay of the clinical course of poisoning with acetic acid, dichloroethane, carbophos, chlorophos, phenobarbital and sodium etaminal in 2538 patients made it possible to define, with the use of the probit analysis, the 25, 50, 75 and 95% concentration thresholds of the lethality in acute poisonings with acetic acid, carbophos and dichloroethane. It was established that under exposure to the toxic substances undergoing different chemical changes in the body, the increase of the lethality risk varied in different age groups. The differences in the structure of outcomes in patients of different age groups formed the basis for making up a classification of the toxicity of the chemical compounds. The differences revealed require a differential approach to the determination of the scope of intensive care of poisonings in terms of the age-associated features.

Acetates↗
PubMedDate not supplied

[The clinico-morphological toxicodynamics of organophosphate insecticide poisonings].

The article deals with investigation of dynamics of clinical morphological pattern in acute poisoning with organophosphorous insecticides. For this purpose all specific and non-specific effects of this chemical disease are classified according to the moment of their occurrence after poison exposure. Morphological equivalent of specific clinical manifestations at different stages of thanatogenesis of this poisoning was determined. It was shown that intensity of pathological process or specific density of toxic effects per time-unit is a very important criterium for assessment of severity and prognosis of poisoning.

Acute Disease↗
PubMedDate not supplied

[The forensic medical aspects of the toxicokinetics of organophosphate insecticides].

The article deals with analysis of toxicokinetics of organophosphorous compounds (malathion and trichlorfon) in blood and of its changes in critical situations (shock, coma). In these forms of viability disturbances provided for mass-transfer and accumulation of poisonous substances in gastrointestinal tract their kinetics was shown to decelerate substantially. Active detoxification therapy improves markedly the parameters of organophosphorous insecticide kinetics. The parameters of toxicokinetics were recommended for use as objective criteria in estimation of intoxication gravity and therapy efficacy.

Acute Disease↗
PubMedDate not supplied

[Expert criteria of the degree of severity of the chemical trauma in acute poisonings by organophosphate insecticides].

The article deals with quantitative assessment of severity of chemical trauma (according to life-threatening characteristics) in case of acute peroral poisoning with OPI (carbophos and chlorophos). Standard diagrams were plotted which help to assess the life threatening values of the given compounds depending on the initial blood poison level or recorded decrease in enzyme cholinesterase activity. Basic opportunity to assess severity of body lesions in case of poisoning with OPI according to character of specific clinical signs was evidenced.

Acetylcholinesterase↗