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Biomedical subjects

V N El'skiĭ

Publications and source records attributed to V N El'skiĭ.

At least 19 recordsLinked to original sources
PubMed1976

[Participation of histamine in activating the hypothalamo-hypophyseo-adrenal system during stress].

In 289 male rats, accumulation of histamine in diencephalon, augmentation of activity in the hypothalamus, and increase of the ACTH content in the hypophysis and 11-OCS in adrenal and plasma were revealed under a functional stress for the hypothalamo-hypophyseal-adrenal system (HHAS). Further accumulation of histamine was associated with increased secretion of CRF, ACTH, and 11-OCS. Blocking of histamine by diphenylhydramine hydrochloride (10.0 mg/kg i. p. -- 30 min before the experiment) depressed the rate and intensity of the initial reaction of HHAS activation.

11-Hydroxycorticosteroids↗
PubMedDate not supplied

[Effect of ionol on peroxidation processes in eye tissues and blood from rats in crush syndrome].

The effect of ionole on the processes of peroxidation in the eye tissues (lens, sclera, cornea, chorioidea) and blood at crush-syndrome has been studied. For the first time in this research work the combination method of the ionole injection has been successfully tested. The ionole injection promoted a decrease in the level of lipid peroxidation products, increase in antioxidations and normalisation in the concentration of phospholipids in the eye-tissues and blood at crush-syndrome. The findings of our study based necessity of inclusion of ionole in the complex treatment of mechanical trauma with the aim of preventing the origin of posttraumatic complication in the eye region.

Animals↗
PubMedDate not supplied

[Appraisal and significance of individual reactivity, daily and seasonal fluctuations of biorhythms, age, sex, and force and multiplicity factor of mechanical effects in the development and outcomes of the shock process].

Experiments were conducted on 944 rats on two models of traumatic shock (prolonged crushing of soft tissues of the thighs, shock after Cannon). A diagnostic index of the severity of traumatic shock (K) was elaborated which showed in conditional units (from 0 to 9) the relation of changes of the skin electric resistance before and after the trauma. The types of the animals' responses were determined and classified according to this index. In severe shock K varied from 2 to 3.5 (the survival of animals did not exceed 24 hours). In moderately severe shock it ranged between 0.8 and 2 or 3.5 and 9 (the survival period was 2-3 days). In mild shock this index ranged from 0 to 0.5 (survival period was 4-5 days). The authors determined the informative significance of some criteria for complex evaluation of the severity of the shock in experiments. According to this significance, the criteria stand in the following diminishing sequence: force of the mechanical effect, factors of individual reactivity (pronounced K index, duration of phase two of its fluctuations), age (weight), time of day, season, sex.

Aging↗
PubMedDate not supplied

[Management of neuroendocrine disorders in traumatic toxicosis using mielopid].

The object of the study was to determine the possibility of using myelopid in correction of the functional condition of the melatonin-opioid and the hypothalamo-hypophyseal-adrenal systems and of the activity of the neurohypophysis in traumatic toxicosis. It was demonstrated in rat experiments that in traumatic toxicosis myelopid modulates synthesis of neuropeptides (melatonin, corticoliberin) and their release into blood plasma. By reducing the blood plasma vasopressin content, myelopid promotes increase in the corticoliberin content in the hypothalamus and increase of 11-OCS biosynthesis in the adrenals. At the same time, the agent increases the melatonin content in the epiphysis cerebri of intact animals and in rats with traumatic toxicosis and reduces the content of leuenkephalin in blood plasma. The role of myelopid in correction of neuroendocrine disorders in traumatic toxicosis is discussed.

Activins↗