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Biomedical subjects

V N Gerasimenko

Publications and source records attributed to V N Gerasimenko.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[Comparative frequency of chromosome aberrations in a human lymphocyte culture depending on the mode of neutron irradiation].

The study of the dose dependence of the incidence of chromosome aberrations in a human lymphocyte culture exposed at the G0 stage to pulsed neutrons of 0.7 MeV revealed no significant distinctions in the cytogenetic effect at the pulse frequency of 1 and 5 Hz, but at 100 Hz it was somewhat increased. As to the biological effectiveness, pulsed neutrons of 0.7 MeV occupied an intermediate position between 0.35 and 0.85 MeV static neutrons.

Cells, Cultured↗
PubMedDate not supplied

[Effect of charged particles of relativistic energy on the number of chromosome aberrations in human blood lymphocytes. Dose-response relationship and the RBE of protons, deuterons and helium ions].

In experiments with human blood lymphocyte culture exposed to fast protons, deuterons and helium ions the frequency and types of chromosome aberrations have been studied. Fast charged particles of a relativistic energy are shown to have a pronounced harmful effect resulting in a sharply increased formation of exchange chromosome aberrations as compared to that produced by gamma-radiation. The RBE coefficients of the particles under study have been determined: their values vary depending on the type of radiation and the tests used.

Chromosome Aberrations↗
PubMedDate not supplied

[Modification by mesoporphyrin-IX derivatives of Chinese hamster cell damage induced by high energy helium ions and protons].

The damaging effect of high-energy helium ions (4 GeV), protons (9 GeV), and standard radiation was different as studied on Chinese hamster cell cultures (clone 431). A possibility of increasing the survival of cells by the pre- and post-irradiation treatment with a mesoporphyrin-IX derivative was demonstrated. It is suggested that the radioprotective effect of the modifier is associated with the decreased level of aberrant mitoses.

Animals↗