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Biomedical subjects

V N Grebeniuk

Publications and source records attributed to V N Grebeniuk.

53 records · Page 3Linked to original sources
PubMed1977

[Study of the antigenic properties of herpesvirus strains isolated from herpetic lesions at different sites].

The antigenic properties of 15 strains of hepesvirus isolated from herpetic lesions of different localization were studied. The serotype of each strain was established by the neutralization tests with hyperimmune sera to the reference type 1 and 2 strains: the cross-neutralization tests revealed antigenic relationships between the strains of 1 and 2 serotypes. Most strains isolated from lesions of the genitalia belonged to type 2, although one strain isolated in herpes genitalis belonged to type 1, and 2 strains isolated from facial lesions also belonged to type 2. These results confirm the necessity of using inactivated polyvaccine prepared from herpesvirus strains of antigenic types 1 and 2 for relapse control therapy instead of using monovalent type 1 and type 2 vaccines as reported by foreign authors.

Antigens, Viral↗
PubMedDate not supplied

[Antiviral activity of experimental combination of 5-iodo-2-deoxyuridine with 6-azauridine and its effectiveness in the treatment of herpetic infection with lesions of the skin and mucous membranes].

The use of the combination of 5-iodo-2-dioxyuridine (IUDR) and 6-azauridine drugs differing in their mechanisms of action in an experimental herpetic infection demonstrated its definite antiviral activity, not only not inferior to the effect of each of the drugs alone, but also remaining sufficiently high when the concentration of IUDR was decreased 2-fold. In clinical trials in relapsing genital herpes all the drugs under study showed statistically significant therapeutic activity. The combined use of the drugs exerted a certain synergistic effect.

Adult↗
PubMedDate not supplied

[Indices of alpha-interferon and of lymphocyte natural killer activity in genital herpes and the effect on them of specific vaccinal therapy and interferon therapy].

Fifty-six patients with recurrent genital herpes (RGH) and 53 normal subjects were examined. No interferon was found in the blood sera of the patients either in the period of the disease relapse or during remission. The leukocyte capacity to produce interferon in vitro (leukocyte interferon reaction, LIR) in the patients was found to be 4-5 times lower than in normal subjects. Study of the normal killer activity of lymphocytes in patients with RGH as compared with that in normal subjects revealed its decrease in 37.5% of the patients and only in 5.1% of normal subjects. Interferon therapy with purified human leukocyte interferon given to 36 patients with RGH resulted in clinical improvement in 88.9% of the patients that was accompanied by increasing normal killer activity of lymphocytes. Vaccine therapy given to 35 patients resulted in a stable clinical effect in 91.4% of the patients, however, without activation of LIR in them. It is concluded that the therapeutic effects of interferon therapy and vaccine therapy have different mechanisms.

Adult↗
PubMedDate not supplied

[Ultrastructural characteristics of a focus of recurrent infection in genital herpes patients (clinical and electron microscopy studies)].

In patients with recurrent genital herpes in the active stage of herpetic infection, herpes simplex virus (HSV) is located both extra- and intracellularly in keratinocytes of the pricky and glandular layers of the epidermis as well as in macrophages and neutrophilic leukocytes. The observed incompleted phagocytosis of HSV by macrophages may be one of the causes of insufficient local resistance to the virus.

Adult↗
PubMedDate not supplied

[Treatment of genital herpes with levamisole in combination with megasine].

The therapeutic effectiveness of levamisole, megasine, and combination of these drugs was studied in 74 patients with genital herpes. Interferon production was first established in the patients treated with levamisole-megasine combination. A direct correlation was established between the therapeutic effectiveness of the drugs and interferon production. Most patients showed varying degrees of the positive effect in treatment with these drugs without any marked side effects. Recurrent genital herpes must be treated with levamisole and megasine for long periods of time.

Adult↗