Biomedical subjects

V N Ivakhnenko

Publications and source records attributed to V N Ivakhnenko.

3 recordsLinked to original sources

PubMed2006

Gestational hypothyroxinemia and cognitive function in offspring.

The effects of gestational hypothyroxinemia on the neurointellectual prognosis of children in the first year of life living in an industrial city (megalopolis) with mild iodine deficiency were studied in 13 children of mothers with thyroid hormone-corrected gestational hypothyroxinemia in the first trimester and 10 children of mothers with normal levels of free thyroxine by assessing cognitive functions at ages six, nine, and 12 months using the Gnome mental development scale. The results showed that maternal free thyroxine levels at the early stages (5-9 weeks) of pregnancy correlated significantly with the coefficients of mental development among the children at ages 6, 9, and 12 months, i.e., represented one of the factors defining the neuropsychological development of offspring. Early (not later than nine weeks) correction of gestational hypothyroxinemia with levothyroxine at a mean daily dose of at lest 1.2 microg/kg improved the neurointellectual prognosis of the offspring, increasing the coefficient of mental development of children to 92-97 points during the first year of life, i.e., to the level of development of mental functions of children born to mothers with normal thyroxine levels.

Child Development↗

PubMed2006

[Cytochemical study of dehydrogenase activity in the tissues of the pig female genital system after injection of xenogenic cerebrospinal fluid (a cytochemical study)].

The experimental study was performed to evaluate the biological effects of parenteral injection of cerebrospinal fluid (SCF) on the uterus, uterine tubes and the ovary of piglets aged 60 days. Lactating cows aged 4-6 years after first calving were taken as SCF donors, since their SCF contained maximal spectrum of biologically active substances. For injection the whole SCF, SCF after passage through bacterial filters and SCF supernatant were used. The effect of SCF was assessed using histological and histochemical (succinate- and lactate dehydrogenases demonstration) methods. It was found that SCF preparations studied had differential effect on oxidative-reduction processes in the tissues of reproductive system organs of immature pigs, that is associated with the broad spectrum of biologically active substances in mammalian SCF.

Animals↗

PubMed1989

[Effect of catamine AB on the generative function and chromosome apparatus of the bone marrow cells in white rats].

In a chronic experiment (6 months) performed on non-inbred white rats effect of cationic superficially active substance catamin AB on the structure and function of male and female gonads, state of the offspring and on the chromosome apparatus of the bone marrow cells has been studied. The preparation is intragastrically injected in doses 10, 1, 0.1 mg/kg. Catamin AB in the dose of 10 mg/kg produces an essential decrease in the specific mass of the testes, reduce in the spermatogenic index, increase in the canaliculi number with exfoliated epithelium, lowered mobility and diminished amount of alive spermatozoa. In the ovary amount of mature follicles becomes less and the number of atresic corpuscles and atresing follicles rises; plethora of the medullary substance occurs in the organ with signs of stasis in the venous bed. In the dose 1 mg/kg catamin AB results in less pronounced changes in the testes and does not produce any pathological disturbances in the ovaries. The preparation does not influence on mating in the test animals, but in the dose 10 mg/kg results in a decreasing fertility because of pre- and postimplantational death of embryos. The changes mentioned are connected with a total toxical effect of the preparation. Catamin AB does not possess any mutagenic effect in the doses tested.

Animals↗