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V N Kirillov

Publications and source records attributed to V N Kirillov.

5 recordsLinked to original sources
PubMed1989

[Effect of ionol on carcinogenesis in the kidneys].

The effect of treatment with an antioxidant--ionol (2,6-di-tert-butyl, 4-methylphenol)--on nitrosodimethylamine-induced carcinogenesis was studied. Large doses of ionol were found to inhibit tumor development in the kidney. This also involved intensification of spontaneous peroxidation of renal cortical membrane cell lipids which in turn was inhibited when additional stimulation with iron was carried out.

Animals↗
PubMed1988

[Effect of the antioxidant fenozan on the physicochemical properties of the kidney cell membranes of rats during nitrosodimethylamine-induced carcinogenesis].

The lipid peroxidation level, microviscosity and arrangement of lipid bilayer in mitochondria and microsomal membranes of kidney cell in rats were increased a month after the treatment with carcinogenic nitrosodimethylamine. The additional injection of antioxidant fenozan-1K prevented the activation of lipid peroxidation in early stage of carcinogenesis and decreased the microviscosity and arrangement of membrane lipids both in early and progressive stages of carcinogenesis, and inhibited the carcinogenic process in the kidneys.

Antioxidants↗
PubMed1988

[Effect of phenozan on nitrosodimethylamine-induced carcinogenesis in rat kidneys].

Fenosan has been studied for its effect on the lipid peroxidation level of mitochondria and microsomes of the rat kidneys in different periods of nitrosodimethylamine-induced carcinogenesis as well as on the incidence of kidney tumour formation. A month after the treatment with the above carcinogen the lipid peroxidation in the rat kidney was activated. An additional injection of fenosan decreased the intensity of the lipid peroxidation and inhibited the tumour development in kidneys. It is supposed that anticarcinogenic action of fenosan is related to the membrane protection from the lesion by the carcinogen.

Animals↗