Biomedical subjects
Publications and source records attributed to V N Kopylov.
Experiments on albino rats demonstrated that high doses of ionising radiation producing pronounced leukopenia increased the animal resistance to pulmonary edema under the effect of adrenaline. This effect was especially manifest on the 4th day of irradiation. Relatively low doses (up to 100 r) as well as separate irradiation of the head, chest, or the abdomen induced pulmonary edema.
Experiments were conducted on 212 albino rats. Preparations giving a marked prophylactic effect in the progress of the lung edema in the nonirradiated animals failed to influence the course of edema and even aggravated it in some of irradiated (650 R) animals. On the contrary, preparations ineffective or negatively influencing the nonirradiated animals were capable of causing a marked prophylactic effect in the irradiated animals. Consequently, the antiedema preventive measures in the irradiated and nonirradiated organisms should be different.
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It was established in albino rats that the activity of the processes that are responsible for the functioning of the metabolic link in noradrenaline synthesis varies under ether and ftorotan anesthesia. It was recorded that there is an increase in the activity of DOPA decarboxylation in the brain under deep ether anesthesia as well as in the activity of dopamine decarboxylation during egress from anesthesia. Ftorotan anesthesia is characterized by increased hydroxylation of phenylalanine and decarboxylation of DOPA, and by inhibition of the activity of tyrosine and dopamine hydroxylation. Egress of animals from ftorotan anesthesia is associated with an intensive noradrenaline formation in the brain.