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Biomedical subjects

V N Rozinova

Publications and source records attributed to V N Rozinova.

12 recordsLinked to original sources
PubMed1988

[The effect of cholesterol oxidation products on the disruption of lipid metabolism and atherosclerotic damage of the aorta in rabbits].

Feeding of rabbits with a cholesterol preparation containing 3-5% of cholesterol autooxidation products promotes elevation of plasma cholesterol and atherogenic low- and very-low-density lipoproteins as well as accumulation of neutral lipids (largely, of cholesterol ether) in hepatocytes and intramural arteries of the myocardium. The development of massive aortic lipoidosis can be also attributed to the intake of relevant products. The similar dose of non-oxidized cholesterol did not induce marked or any changes at all in rabbits lipid metabolism and aortic status. The evidence obtained indicates an essential role of food exogenic products of cholesterol oxidation in mechanisms of hypercholesterolemia development and atherosclerotic involvement of vascular walls.

Animals↗
PubMed1987

[Morphologic features of the endothelial lining of the blood vessels and endocardium].

The endothelial lining (EL) of ventricular endocardium and coronary arteries of a dog, minipig and humans, as well as that of the abdominal aorta of a rat and superior vena cava (minipig) was studied using luminescent microscope in the reflected light after staining of the non-fixed tissue with thioflavine-T and argentation. Marked heterogeneity of the endotheliocytes was shown to be both specific and depending on the localization of the cells in the cardiovascular system. Comparative analysis of EL in different animal species and in man, as well as in different parts of the CVS, indicated the relationship between the cellular morphologic features and local hemodynamics.

Animals↗
PubMed1987

[Decrease in the degree of lipoid infiltration of rabbit tissues during feeding with cholesterol freed from autoxidation products].

Lipid accumulation in the rabbit liver and myocardium has been investigated by histochemical and biochemical methods. The rabbits received cholesterol that contained 5% of autooxidation products or purified cholesterol. Lipid accumulation took place in the liver and intramural myocardial vessels during feeding of rabbits with autooxidated cholesterol. Feeding with pure cholesterol free from autooxidation products caused but slight changes or no changes at all.

Animals↗
PubMed1983

[Morphogenesis of early pre-lipid stages of atherosclerosis].

Investigation of early changes in the aortal wall (focal edema of the intima, rhythmic structures, and primary fibrous plaques) in children and young subjects showed the possibility of nonlipidogenic mode of the development of atherosclerotic plaques. The data suggest that an important role in the genesis of atherosclerotic changes in man is played by local alterations of the arterial wall not associated with disorders in the general lipid metabolism. The local damage of the endothelial lining of the arteries in these sites may be very important in their genesis.

Adolescent↗
PubMed1981

[Arterial endothelium in human atherosclerosis].

Endothelium above the lipid streaks, lipid-fibrous and fibrous plaques in the right coronary artery and the brachial artery of 11 cases of sudden death of males and females aged 22-65 was examined in flat film preparations. The foci of atherosclerotic injuries are covered with deendothelized areas, blood platelets, leucocytes, and other blood cells, with clots of vascular smooth muscle cells. The endothelium is considerably changed; these phenomena evidence an injury of the endothelium and its regeneration in zones of atherosclerotic lesions.

Adult↗
PubMed1981

[Fibrous lipid plaque formation in young people].

The study of the fibrous lipid plaque formation in young subjects showed that the proliferation of the smooth muscle cells in the arterial wall intima was the primary process in the genesis of the atherosclerotic lesions. The hypoxic alterations and metabolic deterioration of the vascular wall occur at the sites of the proliferation of smooth muscle cells and focal hyperplasia. This results in the obesity of the smooth muscle cells and increased permeability for plasma proteins, which intensifies even more the focal intimal sclerosis. The necrosis and degradation of the smooth muscle cells "overloaded" with fat in the centre of the plaque result in the release of lipids into the extracellular space and in the formation of atheroma. Further progressing of atheroma occurs due to the involvement of the new "foamy" and smooth muscle cells, located in its periphery, but not due to the immediate lipid deposition from the arterial lumen.

Adolescent↗
PubMed1980

[Smooth muscle cells of the arteries and arteriosclerosis].

The review presents information on proliferation of smooth muscle cells (SMC) of the arterial wall as the key moment in atherogenesis. Some factors influencing SMC proliferation as well as some aspects of SMC biology the knowledge of which is necessary for better understanding of some current hypotheses of atherosclerosis are considered. SMC proliferation has been recognized as the main cause of atherosclerosis relatively recently. Each of the original theories or hypotheses of the atherosclerosis pathogenesis under consideration is focused on different factors underlying SMC proliferation and deals with the problems the resolution of which helps better understanding of the causes and genesis of this disease.

Aging↗
PubMed1980

[Focal edema of the intima as a preatherosclerotic arterial lesion].

A number of histological, histochemical and immunomorphological methods were used to study focal edema of the aortal intima in children and young subjects and its association with the development of atherosclerotic alterations. The main manifestations of the focal edema of the intima include focal accumulation of insudate consisting of serous or serous-fibrinous liquid, accumulation of metachromatic substances, damage of collagen and elastic fibers, proliferation of smooth muscle cells and their fatty metamorphosis. Later, signs of organization and sclerosis of the edematous zone develop. The following stages of the development of focal intimal edema may be distinguished: simple or serous edema; serous-fibrinous edema; proliferation of smooth muscle cells followed by their fatty degeneration and extracellular release of lipids; organization or sclerosis of the edema focus. It is assumed that late stages of the development of focal edema of the intima are associated with fibrous and fibrous-lipid atherosclerotic plaques.

Adolescent↗
PubMed1976

[Morphological and histochemical changes in the rabbit aorta during exogenous and endogenous hyperglycemia].

Alimentary hyperglycemia and insulin deficiency were accompanied in rats by atherosclerotic affection of the aorta whose degree increased in feeding of cholesterol to such animals. The detected morphological and histochemical changes in the wall of the aorta correlated with the biochemical atherogenic shifts in the blood serum of the corresponding animals groups established earlier.

Animals↗
PubMedDate not supplied

[Conduit drainage and preserved amnion in pathologies of the cornea concomitant with glaucoma].

The authors improved the anterior-chamber bypass technique implemented simultaneously with reconstructive penetrating keratoplasty or with trabeculotomy in order to enhance the efficiency of antiglaucomatous drainage surgeries in organic lesions of the anterior segment of the eye combined with active inflammatory processes in it and concomitant with secondary glaucoma. The use of conduit drainage was supplemented with wrapping the distal end with conserved amnion, which prevented the postoperative obstruction of drainage or its heading in the outward direction. Amnion, exceeding the size of the scleral flap, was placed in trabeculotomy with active inflammatory signs between scleral strata, thus, preventing an excessive postoperative scarring. A total of 45 patients were operated on with the follow-up reaching 3 years. The efficiency of antiglaucomatous interventions made up 88-93% of cases. The suggested new drainage techniques with conserved amnion can be successfully used surgeries combined with keratoplasty as well as in independently in secondary glaucomas of various etiologies and in primary refractive glaucoma.

Adolescent↗