[Age related peculiarities of the relationship among a functional indicators of intracranial hemo- and cerebrospinal fluid dynamics].
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Adolescent↗
Biomedical subjects
V N Semernia
Publications and source records attributed to V N Semernia.
[Measurement of total cerebral blood flow in man by means of the hydrogen clearance method].
The authors discuss a new method for measuring the overall cerebral blood flow in man from analysis of the hydrogen clearance curves recorded in the internal jugular vein with a sounding platinum electrode. The hydrogen clearance curves are polyexponential in character and for calculating the blood flow it is therefore necessary to use the stochastic method. The use of the "initial inclination" method is also admissible in proximate curve analysis. The values of the overall cerebral blood flow in patients with craniocerebral injury measured by the method suggested are in agreement with the data in the literature.
Cerebrovascular Circulation↗
[Cerebral blood flow and cerebrovascular reactivity in the early postnatal ontogeny of rats].
The development of cortical cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) were studied in Wistar rats during early postnatal ontogenesis, in groups aged 2-5, 6-8, 9-11, 12-15, 16-18 and 19-25 days. CBF was measured polarographically using inhaled hydrogen clearance method, with platinum electrodes inserted into parietal cortex. At the mentioned age periods, CBF and its percentage of adult level averaged as 38 (21%), 81 (45%), 142 (78%), 85 (47%), 110 (61%), and 118 (65%) ml/100 g/min, respectively. Hence, during the early postnatal ontogenesis CBF increased gradually, however, it did not reach the adult level up to the end of the first month. CBF peak at 9-11 days period is suggested as a result of sharp rise of the brain vessels growth. CVR was assessed as the percentage of CBF increase after standardized 5% CO2 inhalation test. At the above age periods, CVR was found to bi 26, 33, 36, 41, 44 and 31% respectively, and was similar to adult rat CVR of 36%. The conclusion was drawn that regulatory mechanisms of adequate responses of brain vasculature to chemical metabolic factors are well developed already at the very beginning of postnatal life.
Aging↗