Biomedical subjects
Publications and source records attributed to V N Shabalin.
Information is presented on the new scientific line in medicine and biology: bio-liquid morphology. The interdisciplinary character of the given research area is emphasized. The problems and prospects of bio-liquid morphological analysis development both in applied and fundamental aspects are discussed.
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The data and theoretical points given in the paper mould basically new views of molecular relationships underlying the function of living beings and biological rhythms. The authors' procedure for wedge biological fluid dehydration reveals a wide autowave spectrum that is clearly detectable when the fluid passes into the solid phase. A hypothesis of the autowave interaction of biologically active molecules is forwarded, which considers autowaves as a basis of organization of physiological and pathological processes occurring in the body.
Bronchial asthma (BA) course and menopausal features were studied in 58 perimenopausal women. Effects of menopause on BA clinical manifestations were considered. 19 patients on climonorm therapy were examined immunologically. It was found that premenopause and perimenopause deteriorate BA clinical picture whereas hormone replacement therapy with climonorm produce a positive effect on menopause and BA. In long-term hormone treatment it is necessary to follow up immune status.
Analytical parameters of instrumental methods of the element analysis of biomedical objects are compared and the place occupied by x-ray fluorescent analysis (RFA) among them is demonstrated. The methods for preparing the specimens of liquid media of the organism and the RFA are simple, rapid, involve no disintegration of the sample, and allow measurements of elements at sigma 1 = 0.02 at concentrations of 12 micrograms/ml. The method is preferable and promising for some basic elements (P, S, Cl, K, Ca), which are difficult to measure by other methods. The levels of S, K, Ca, Fe, Zn, and Cu were measured in erythrocytic mass and blood serum of normal subjects, patients with asthma and aplastic anemia, and recipients of allogenic kidneys.
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Time course of the immunity system parameters was followed in children suffering from grave endotoxicosis forms treated by discrete plasmapheresis (DPA) as the emergency therapeutic measure. T, T-active, B lymphocytes, O cells, immunoglobulins A, G, M were analyzed, as were the counts of phagocytizing leukocytes and circulating immune complexes. The infectious process was found to lead to a temporary relative secondary immunodeficiency. DPA with perfusion of hyperimmune plasma resulted in rapid correction of all component of the immunity system, paralleled by normalization of the general clinical status of the patients, and prevented chronic transformation of the process.
Association has been detected between incidence of HLA-antigens and allergy prevalence in Koreans. Antigen B8 occurs significantly more frequently whereas A3 more rarely in Koreans with allergy. Determination of HLA-antigens distribution may be helpful in prognosis of allergic diseases possibility. Allergies are a rare finding in Koreans due to less common occurrence of antigens AI and B8 in them against Europeans.
The data on the results of clinico-immunological examination of 46 infants having purulent inflammatory infections in the first month of their life and treated with (a) immunoglobulin for intravenous injection, (b) with hyperimmune antistaphylococcal plasma and immunoglobulin for intravenous injection and (c) without the use of specific hyperimmune preparations are presented. The clinico-laboratory data thus obtained (the levels of serum immunoglobulins and the content of T-rosette-forming lymphocytes) are indicative of the expediency of including the intravenous injection of donor immunoglobulin into the complex therapy of newborn infants with severe and moderate forms of purulent inflammatory infections at an early period of the disease irrespective of its etiology.
A review of investigations has been made conducted in the USSR and abroad on the production of combined polyfunctional hemotransfusion media--red blood cell suspensions in plasma-substituting solutions possessing preservative properties and hemodynamic action. The advantages of the hemotransfusion therapy with the use of these media have been shown associated with the diminution of the risk of posttransfusion complications and reactions (especially under extreme conditions) and depending on economic aspects. The properties of red blood cell suspension in the modified deionization gelatin solution have been considered in detail.
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