[Interrelation between circulating and fixed anti-tissue autoantibodies in patients with leukemia].
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Biomedical subjects
Publications and source records attributed to V N Shabalin.
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The method of wedge-type dehydration was made use of to study the specificity of the systemic structure of 496 samples of aqueous humor obtained in the course of surgical interventions in 62 patients for senile cataract. The results were analyzed with respect to a cataract stage and it was established that the systemic structure of aqueous humor reflects different-phase impairments in the system of the intermolecular interaction of aqueous-humor components, which is mainly related with activated processes of organic products' mineralization as observed in senile cataract progression.
The parameters of the wedge dehydrated samples of aqueous humor and tear taken from patients with senile cataract were compared by a morphometric assay. Computer-aided processing of the images of the test biological fluids was made on a Morphotest-1 hardware-software complex. The study has provided evidence for the uniformity of distribution of major structural components in the dehydrated samples of tear and aqueous humor in each specific examinee. This fact opens up possibilities for studying the signs of different intraocular pathological conditions from the morphological pattern of tear.
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Changes in the incidence of the HLA system antigens (A1, A2, A3, A9, A10, A11, A19, A28, A29, B5, B7, B8, B13, B14, B15, B16, B17, B18, B21, B22, B27, B35, B37, B40, B41) was studied in 1134 healthy persons and in 147 patients with diabetes mellitus. In comparison with healthy persons, patients with juvenile diabetes mellitus (62) displayed a significant increase in the incidence of antigens B8, B15, B35, and A10, and patients with adult diabetes mellitus with normal weight (35)--of antigen B8. When adult diabetes mellitus was accompanied by obesity (50) a significant rise in the occurrence of antigen A10 was revealed.
Until recently, the diagnosis of urolithiasis has been made by its complication--an apparent calculus in the kidney. We have discovered the phenomenon of pathological crystallization of urinary lithogenetic salts. Now, basing on this phenomenon we are able to make a diagnosis of urolithiasis at its preclinical stage, i.e. before the appearance of renal calculus, to control the course of urolith formation and to find out composition of the stone. We propose a complex of original techniques (Litos system) which provides pathogenetic diagnosis of urolithiasis.
It is known that when drying a drop of biological liquid under the action of osmotic forces acquires certain structure. The salts, which possess stronger osmotic potential, undergo crystallization in the center of the drop while protein components form the peripheral amorphic zone. In urolithiasis this process is impaired and crystallization of lithogenic salts occurs in the protein zone of a urine drop. This phenomenon discovered by the authors is designated as phenomenon of pathological crystallization of urine lithogenic salts. In nephrology and urology the above phenomenon may find application in diagnosis and control of urolithiasis activity, assessment of efficacy of the treatment conducted.