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Biomedical subjects

V N Sokrut

Publications and source records attributed to V N Sokrut.

At least 19 recordsLinked to original sources
PubMed2000

[The change of biogenic amine blood level under the influence of the low intensity laser infrared radiation].

The dynamics of the biogenic amines level in the blood of patients after performance of hemorrhoidectomy was dependent on severity of an organism stress-reaction predicting the wound healing outcome. When the wound irradiation using the low-energy laser of infrared diapason is performed in patients with the lowered reactivity of organism the histamine and serotonin contents dynamics is the same as in the patients with normal reactivity.

Adult↗
PubMed2000

[Noncomplicated and complicated healing of wound in patients after hemorrhoidectomy].

Complicated and noncomplicated forms of rehabilitational process course after hemorrhoidectomy are delineaed. There were studied up an organism reactivity, the peroxidal oxidation of lipids intensity, the dynamics of the biogenic amines contents. The dependence of the inflammation severity in the wound from severity of the organism stress-reaction on operative intervention was established. In patients with normal reactivity the noncomplicated healing of operative wound was observed. In patients with lowered or enhanced reactivity there were observed the reduction of the antioxidant system limiting activity, disbalance of pro- and antioxidation systems, the biogenic amines dynamics change with long drawn-out course of inflammatory reaction and with complicated healing of operative wound.

Hemorrhoids↗
PubMed1991

[Biochemical characteristics of uncomplicated and complicated healing of experimental myocardial infarcts].

Myocardial infarction was simulated in experiments with 138 dogs showing normal, high, and low responses. The kinetics of creatine kinase as a marker of necrotic processes in myocardial infarction was shown to accelerate with hyperreactivity and to slow down with hyporeactivity. The kinetics of ů-glutamyl transpeptidase as a marker of reparative processes in myocardial infarction was characterized by delayed and slower evolution in hyper- and hyporeactivity. The kinetics of dienic conjugates, cyclic nucleotides (cAMP, cGMP) and immunoreactive insulin was also determined largely by the body's reactivity and the types of experimental myocardial infarction healing and was closely related to that of enzymatic markers of necrotic processes.

Adrenocorticotropic Hormone↗
PubMed1990

[Blood plasma diene conjugates in uncomplicated and complicated forms of the healing of experimental myocardial infarct].

The experiment on 39 dogs has shown that in MI the concentration dynamics of conjugates in the blood plasma is in accordance with the forms of its healing and has two periods of activation related, respectively, to necrotic processes and development of granular tissue in the infarction zone. The control over the changes of peroxide lipid oxidation (PLO) in MI may be regarded as one of the methods of diagnosing and foreseeing the outcomes of its healing. In optimization of MI healing, to modulate PLO appears to be advisable, that is, to make its course typical of noncomplicated MI.

Aminopyrine↗
PubMed1990

[The expediency of optimizing lipid peroxidation in treating complicated forms of myocardial infarct healing].

Experiments on 36 dogs revealed a relationship of inhibition and stimulation of lipid peroxidation (LPO) and reactivity of myocardial infarction (MI) concerning outcomes of healing. It is shown that in complicated IM it is necessary to optimize LPO turning its dynamics to uncomplicated disease forms. In hyperreactive MI it is judicious to use antioxidants while in hyporeactive LPO stimulation is indicated using ultraviolet radiation of the blood.

Aminopyrine↗
PubMed1989

[The use of anti-inflammatory agents and stimulators of reparative processes in myocardial infarction].

Agents effecting healing of the infarction zone were used in treatment of 326 patients with macrofocal myocardial infarction. In hyporeactive myocardial infarction stimulators of reparative processes, namely, methyluracil, sodium nucleinate, riboxin, retabolil, phenabolil). In hypereactive myocardial infarction antiinflammatory agents (amidopyrin, butadion, ibuprophen, indomethacin and oth.) were used beginning with the first days while stimulators of reparative processes were used beginning with the 3-4 days. Inclusion into treatment of agents optimizing healing of the myocardial infarction improved the clinical course of the disease, reduced manifestations of cardiac insufficiency and disorders of the cardiac rhythm.

Adult↗
PubMed1989

[Topological features of DNA synthesis in the left ventricular wall during the repair of the heart after myocardial infarction].

In the experiment with 18 dogs it was shown, that the intensity of the synthesis processes of the heart tissue when the myocardial infarction occurs, after some reduction on the first day, subsequently increases. The activation of the DNA synthesis is the most marked in the peri-infarctional zone and distal to the infarctional zone. To the end of the granulation tissue maturation the intensity of the synthesis processes gradually becomes normalized.

Animals↗
PubMedDate not supplied

[Calcium and calcium-channel blockers in the healing of an experimental myocardial infarct].

It has been shown in experiments on 36 dogs with experimental myocardial infarction (MI) that the effect of calcium and blockers of calcium channels largely depends on the initial condition of reactivity and is realized via changes in lipid peroxidation (LPO). In MI, calcium enhances necrotic processes whereby aggravating disorders in its healing in case of high reactivity and returns them to normal, thus contributing to optimization of its healing in animals with low reactivity. Calcium channels blockers attenuate necrotic processes associated with MI and lead to its better healing in the presence of high reactivity and aggravate disorders in its healing in animals with low reactivity. Consideration of the body reactivity, the differentiated use of calcium drugs and calcium channels blockers should be regarded as an effective approach to optimization of the healing of complicated forms of MI.

Aminopyrine↗
PubMedDate not supplied

[Kinetics of myoglobin, creatine kinase and aspartate aminotransferase in uncomplicated and complicated forms of healing of experimental myocardial infarction].

It was demonstrated in experiments on 60 dogs that in hyporeactive myocardial infarction (MI) myoglobin (MG) concentration and the activity of creatine kinase (CK) and aspartate aminotransferase (ASAT) increase at a slower rate and reach maximum values later. In hyperreactive MI the rate of their increase and the time of attainment of maximum values are, respectively, greater and earlier than in normoreactive MI. The connection of MG, CK, and ASAT changes with reactivity allows them to be used in prognosticating MI healing.

Animals↗
PubMedDate not supplied

[The efficacy of glucosamine in treating complicated hyperreactive experimental myocardial infarct].

The effect of glucosamine hydrochloride on the course of complicated hyperreactive myocardial infarction in dogs was studied. Glucosamine contributed to the restoration of reactivity in the animals. The reactivity became corresponding for normoreactive myocardial infarction. Glucosamine normalized carbohydrate and protein metabolism in the necrosis zone, cAMP and cGMP and also their ratio that led to healing by postinfarction scar, and in none of the cases the heart aneurysm developed. The optimizing healing of hyperreactive myocardial infarction under the influence of glucosamine is mediated through the mechanisms of reactivity and the regulation of metabolic processes.

Adrenocorticotropic Hormone↗
PubMedDate not supplied

[Blood plasma diene conjugates during the stimulation and inhibition of lipid peroxidation in dogs with different forms of healing in experimental myocardial infarct].

In experiments on 45 dogs with a model of normo-, hyper-, and hyporeactive myocardial infarction, (MI) lipid peroxidation (LP) was stimulated by ultraviolet irradiation of autologous blood and inhibited by alpha-tocopherol acetate. It is shown that changes of LP are characteristic of uncomplicated healing of normoreactive MI. Hyperactivation of LP in hyperreactive MI and its hypoactivation in hyporeactive MI are among the factors of complication of its healing by postinfarction aneurysm of the heart. LP modulation consisting in bringing its changes in conformity with those in uncomplicated forms of the disease facilitates normal MI healing with the formation of a postinfarction scar. Antioxidants are indicated in hyperreactive MI, and LP activation by means of stimulators is recommended in hyporeactive MI.

Animals↗
PubMedDate not supplied

[The effect of hyperglycemia on the development of experimental myocardial infarct].

Experiment on 72 dogs has shown that myocardial infarction (M1) against a background of hyperglycemia proceeds as shifts healing hyperactive MI. Shifts in carbohydrate metabolism results in disturbances of dynamics of the necrotic infarction zone processes that induces complications of healing changes in the content of myoglobin, creatine kinase, aspartateaminotransferase with MI against a background of hyperglycemia greatly differ from those typical of noncomplicated and complicated hyperactive MI.

Animals↗
PubMedDate not supplied

[Effect of reactivity disorders on the healing process in myocardial infarction].

Normo-, hyper-, and hyporeactive myocardial infarction was modelled in experiments on 38 dogs. Reactivity disorders complicating healing of the infarct are mediated through desynchronization of the necrotic and reparative processes. Increase of reactivity leads to acceleration, while its diminution leads to deceleration of the necrotic processes with delay in the development of reparative processes.

Animals↗