PubMed Health⌕ Search

Biomedical subjects

V N Titov

Publications and source records attributed to V N Titov.

At least 55 records · Page 3Linked to original sources
PubMed2002

[Diagnostic significance of albumin transporting characteristics and blood level of troponin T in myocardial infarction].

Serum albumin binding capacity (ABC) was studied using K-35 hydrophobic fluorescent probe in order evaluate the passive transfer and absorption of saturated fatty acids (s-FA) by the cells. ABC decreases on day 3 of myocardial infarction and remains low till discharge and is paralleled by hyperTG. We believe that ABC decrease reflects activation of passive transfer and absorption of s-FA by the cells during simultaneous blocking (presumably by acute phase proteins) of active apoE/B-100 receptor endocytosis of s-FA in the form of TG as VLDL remnants. Decrease of ABC reflects a later than erythrocyte sedimentation rate and acute phase proteins normalization of metabolic consequences of inflammation. ABC helps indirectly evaluate the blocking of active (receptor) absorption of s-FA in the form of TG and activation of passive absorption of s-FA from associations with albumin by the cells.

Aged↗
PubMed2002

[Double bonds of fatty acids, alcohols glycerol, cholesterol and nonpolar serum lipids. Diagnostic value of hypercholesterolemia].

A method for evaluation of double bonds (DB) by ozone titration in a pool of serum lipids during extraction after Folch is developed. A method for measuring the weight of nonpolar lipids in apoB-100-lipoproteins (LP) with a hydrophobic fluorescent probe K-37 was used. Cholesterol and glycerol alcohols were measured in the serum using Cholesterol and Triglycerides kits (Hoffmann la Roche). Twenty-four patients with myocardial infarction, 29 coronary patients, and 37 healthy children were examined. The level of cholesterol alcohol reflects the number of double bonds in fatty acids (FA) and hence, the content of essential polythenic FA in the serum. The higher the level of cholesterol alcohols the greater the pool of essential poly-FA, circulating in the blood as nonpolar cholesterol polyesters within low density lipoproteins (LDL). Presumably, the higher the level of cholesterol LDL, the more pronounced is the deficit of essential poly-FA and the greater is the compensatory activation of the synthesis of endogenous poly-FA. A positive correlation between the content of cholesterol alcohol in the serum and weight of nonpolar lipids in apoB-100-LP was noted.

Adolescent↗
PubMed2002

[Effect of hormone replacement therapy on blood serum lipids in postmenopausal women with type 2 diabetes].

There are limited data concerning influence of hormone replacement therapy (HRT) on lipid profile in women with type 2 diabetes. Aim of the study was to compare changes of blood lipids during HRT in postmenopausal women with and without type 2 diabetes. Seventy seven women included in the study were assigned to 1 of 4 groups, basing on being diabetic or nondiabetic, and further subdivided into users of estrogen alone (ERT), and of estrogen plus progestin (EPRT). Effect of 6-month ERT (oral estradiol valerate 2 mg/day) and EPRT (oral estradiol valerate 2 mg/day sequentially combined with cyproterone acetate 1 mg/day) on total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides and lipoprotein (a) [Lp(a)] was separately assessed. EPRT and ERT caused decrease in LDL-C by 15% and 12%, and increase in HDL-C by 12% and 13%, respectively, in patients with diabetes (p<0.05 in all cases). LDL-C decreased by 11% and 15%, respectively, in women without diabetes (p<0.05 in all cases). Lp(a) was also reduced 25% with EPRT (p<0.01) and ERT (p<0.05). HDL-C increased 10% (p<0.05) with ERT but remained unchanged with EPRT. In conclusion, changes in all lipid parameters except Lp(a) caused by ERT and EPRT were comparable in postmenopausal women with and without type 2 diabetes.

Aged↗
PubMed2002

[Prognostic value of cardiac troponin I in patients with non-ST elevation acute coronary syndrome].

AIM: To elucidate relationship between initial blood levels of troponin I and occurrence of such events as death, myocardial infarction, coronary artery bypass surgery, and angioplasty in patients with non-ST elevation acute coronary syndrome. MATERIAL: One hundred one patients aged 32-78 years admitted to coronary care unit within 24 hours after onset of pain including 69 (68.3%) with unstable angina and 32 (31.7%) with non-ST elevation myocardial infarction. METHOD: Troponin I was determined by immunoassay, values below 0.4 ng/ml were considered normal. RESULTS. During 30 days of hospitalization there were 16 (35.5%) and 5 events (8.9%) events (p=0.001) among 45 patients who had elevated level of troponin I (group 1) and 56 patients with normal troponin I (group 2), respectively. By 6 months events occurred in 19 (42.2%) and 6 (10.7%) patients in groups 1 and 2, respectively (p=0.0004). CONCLUSION: Thus elevated blood level of troponin I in patients with non-ST elevation acute coronary syndrome has important value for prognosis.

Acute Disease↗
PubMed2002

[Effect of atorvastatin on endothelial function in patients with familial hypercholesterolemia].

AIM: To study the influence of treatment with HMG-CoA reductase inhibitor atorvastatin on endothelial function in patients with familial hypercholesterolemia type IIa. MATERIALS AND METHODS: Sixteen patients (5m/11w, 51-/+3 years) with familial hypercholesterolemia were studied before and after 3 months of therapy with atorvastatin 20 mg/day. EDRF release test (D.Celermajer, 1992) was used to assess flow-mediated endothelium-dependent vasodilatation (FMD) of the brachial artery in response to reactive hyperemia. Plasma nitrite/nitrate (NOx) levels were measured as an indirect index of nitric oxide (NO) production in vivo using HPLC. RESULTS: Atorvastatin treatment resulted in a 32% reduction in total serum cholesterol (CH), 41% reduction in low density lipoprotein (LDL) CH, 16% reduction in triglycerides and a 21% increase in high density lipoprotein CH. Flow mediated dilatation (FMD) was impaired at baseline (5.8-/+0.9%) and significantly improved up to 9.5-/+0.9% after 3 month atorvastatin therapy (p<0.002). Change in FMD inversely correlated with baseline FMD (r = -0.58, p<0.05). There was no significant correlation between FMD and neither total serum CH nor LDL CH levels at baseline. During atorvastatin therapy significant reduction of plasma NOx levels occurred from 53.4-/+5.1 mcmol/l at baseline (range 42.6-86.2 mcmol/l) to 35.5-/+5.1 mcmol/l (18.4-46.0 mcmol/l) after treatment (p<0.02, n=7). CONCLUSION: In patients with familial hypercholesterolemia atorvastatin produced beneficial effect on endothelial function (increase in flow-mediated dilatation, decrease in NOx).

Adult↗
PubMed2002

[Proportion of alcohols of cholesterol, glycerol and double bonds of fatty acids in blood serum and lipoproteins. Diagnostic significance of hypercholesterolemia].

A new method in quantitative determination of double bonds (DB) in the pool of fatty acids (FA) has been worked out by ozone titration after extraction of lipids according to Folch. A correlation was observed among DB content, the level of cholesterol alcohol (CS, r = +0.612; p < 0.001) and the level of glycerol (GL) alcohol (r = +0.392; p < 0.01). The grown-ups with ischemic heart disease and children have a constant ratio (5.05 +/- 0.18) DB:CS ratio.

Adolescent↗
PubMed2001

[The content of double bonds in blood serum lipids from patients with myocardial infarction].

Hypocholesterolemia and hypotriglyceridemia during the first days of myocardial infarction (MI) is a result of enhanced absorption of saturated fatty acids in the form of triglycerides within very low density lipoproteins (VLDL) through apoE/B-100 receptors. This is followed by inhibition of this endocytosis, accumulation of saturated fatty acids VLDL in the blood, and hypertriglyceridemia. Permanent level of double bonds in MI (ozone titration) results not from MI but from blocking of cell absorption of polyenic fatty acids in the form of cholesterol polyesters in low-density lipoproteins (LDL) through apoB-100 receptors, which is characteristic of atherosclerosis. High molar ratio of double bonds/cholesterol in comparison with the double bonds/glycerol ratio indicates that the majority of polyenic fatty acids in the blood lipoproteins present as cholesterol polyesters. Lipoprotein transfer and cell absorption of saturated fatty acids alone are selectively impaired in MI. Selective impairment of cell absorption of saturated or polyenic fatty acids alone or a combination of both is observed in some diseases. Ozone titration of serum lipid double bonds reflects impaired absorption of essential polyenic fatty acids by cells.

Adult↗