Biomedical subjects

V Nadarajah

Publications and source records attributed to V Nadarajah.

4 recordsLinked to original sources

PubMed1997

Use of panoramic radiography among an ambulatory dental population to detect patients at risk of stroke.

Panoramic radiographs of 3.6 percent of 1,175 newly accepted dental school patients displayed calcifications in the area of the carotid vasculature. The authors interviewed the patients with calcifications to determine whether they exhibited any recognized atherosclerosis, risk factors. One patient had symptoms of atherosclerosis, and a statistically significant correlation was found for obesity among the patients interviewed. The authors concluded that panoramic radiography is useful for identifying some asymptomatic patients with carotid calcifications. These patients should be referred to their physicians promptly for a cerebrovascular work-up as part of an active stroke-prevention strategy.

Adult↗

PubMed1997

Local inflammatory effects of composite resins.

Composite resins have been widely used as an anterior restorative material and often have been used to restore posterior teeth. However, composites occasionally can become embedded in oral soft tissues during finishing or shaping procedures, which can lead to persistent chronic inflammation. Limited evaluation in animal model systems has shown that this entrapment in soft tissues can sometimes lead to local inflammation in adjacent soft tissues. Consequently, finishing and polishing procedures should be performed, where practical.

Animals↗

PubMed1996

Localized cellular inflammatory responses to subcutaneously implanted dental mercury.

Previous reports have demonstrated mercury accumulation and toxicity in oral tissues following exposure to mercury vapor from dental amalgam restorations. In the present study, inflammatory responses to subcutaneously administered mercury were assessed histopathologically and immunocytochemically in a rat model system. A panel of six well-characterized monoclonal antibodies specific for monocytes, macrophage subsets, T and B lymphocytes, and major histocompatibility complex (MHC) class II (la) determinants was used to quantitate alterations in mononuclear cell subsets in situ at time intervals from 2 d to 8 wk. The results revealed acute inflammatory cell infiltration at 2 and 3 d, followed by chronic inflammation that persisted after 8 wk. The numbers of monocytes, resident macrophage subsets, and mononuclear cells expressing la antigen were significantly different from control tissues at 1-2 wk. The numbers of resident macrophages remained significantly higher even after 8 wk. These data showed that in situ mercury accumulation can lead to altered expression of MHC class II determinants with persistent chronic inflammation and shifts in mononuclear cell subpopulations.

Animals↗

PubMed1996

Cellular inflammatory responses to implanted dental materials.

Cellular inflammatory responses to subcutaneous implantation of amalgam and composite resins were assessed in rats by use of histologic and immunocytochemical methods 2 days to 8 weeks after implantation. Frozen and paraffin sections were obtained from subcutaneous tissues associated with amalgam and composite resin suspensions. The amalgam induced mild inflammation with proliferation of few resident macrophages, but implantation of composite resins was associated with an influx of monocytes, increased numbers of resident connective tissue macrophages, and abnormal major histocompatibility antigen class II (Ia antigen) expression. The data suggest that composite resins may produce a a more pronounced inflammatory response than dental amalgams do when incorporated in soft tissues.

Animals↗