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Biomedical subjects

V Neagu

Publications and source records attributed to V Neagu.

11 recordsLinked to original sources
PubMed1981

Potential anticancer agents. XXII. Pharmacological properties of some new triazene derivatives.

The pharmacological properties (toxicity and antitumor activity against W256 carcinosarcoma and L1210 leukemia) of thirty five new triazenes derived both from amides and esters of 3-methyl-4-amino-benzoic acid and from aromatic dipeptidic esters were investigated. The new compounds proved to be moderately effective against W256 carcinosarcoma and totally devoid of activity against L1210 leukemia, except for ethyl,4-(3,3-dimethyltriazenophenyl)-N-alpha-(9-fluorenyl)-acetyl-L-alanine ester which exhibited borderline activity against this leukemia. The pharmacological data thus obtained were correlated with the physico-chemical parameters of the new triazenes in a quantitative structure-activity relationship (QSAR approach). The results of the computed equations suggested that the electronic and the lipophilicity factors alone are not sufficient to give a satisfactory picture of the in vivo behavior of such compounds.

Animals↗
PubMed1979

Urinary lithiasis associated with urinary tuberculosis.

In a series of 2,500 patients with urinary tuberculosis, 74 cases evidenced an associated lithiasis (2.96%). Intensifying and amplifying the noxious effects, the association of these affections is misleading. Referring to the published data and their own experience, the authors therefore draw attention to this association which although relatively rare, is important because of the diagnostic problems it involves.

Adult↗
PubMed1978

Juxtavesical hydatid cysts.

Out of 177 different hydatid localisations 9 were juxtavesical. In 3 patients the cysts were recurrent. The diagnosis, based on the clinical and radiological examinations and exploration was facilitated by the history or the co-existence of other parasitic lesions. Other pathological lesions in 2 patients brought about hesitation and delay in micturition. In one case, size, consistency and fixation of the cyst initially suggested a malignant pelvic tumour. One severe late renal complications was recorded. 7 patients underwent surgical treatment.

Adolescent↗
PubMed1978

Improved suprapubic vesical drainage in transvesical prostatectomy.

An improved drainage is used in transvesical prostatectomy in order to avoid urinary retention after removal of the Novak-type suprapubic drainage with bladder neck cerclage haemostasis (described by some authors in 1975). The causes of urinary retention are analysed, the drainage technique as well as the mechanisms eliminating the above-mentioned complications are described.

Humans↗