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Biomedical subjects

V Neppe

Publications and source records attributed to V Neppe.

8 recordsLinked to original sources
PubMed1995

Drug-induced seizures in the elderly. Causative agents and optimal management.

We conducted a review of drugs that were most commonly associated with inducing seizures in the elderly population. The method for determining the risk of these agents includes evaluating the utilisation and the percentage of adverse events in previous studies and case reports. Classes of medications, such as anti-psychotics and antidepressants, are extensively reviewed to provide the clinician with treatment options in high risk patients. The risk of seizures secondary to the withdrawal of alcohol (ethanol) and benzodiazepines, and methods employed to minimise the risk are discussed. In addition, the management of patients with drug-induced seizures is delineated. Drug-induced seizures are a potentially serious adverse effect. It is important that clinicians are aware of which classes of medications and individual medications are associated with reducing seizure threshold.

Aging↗
PubMed1994

Amnesia and vegetative abnormalities after irradiation treatment: a case study.

This paper describes a case of a patient (GX) with a brain tumour in the third ventricle who developed a syndrome of amnestic disorder and vegetative abnormalities (hyperphagia, oligodipsia) after irradiation treatment that followed brain surgery. The patient shows an extremely poor long-term memory on both visually and verbally presented material, and of autobiographical events occurring after the onset of the illness, but some preserved memory functions on short-term memory tasks, semantic memory tasks, and implicit memory tasks. Given the onset of symptoms only after irradiation (a memory deficit in particular), and the non-invasive nature of the surgery, the probable etiology is post-irradiation syndrome.

Adult↗
PubMed1992

The application of the Screening Cerebral Assessment of Neppe (BROCAS SCAN) to a neuropsychiatric population.

Assessments of higher cortical functioning are often neglected in patients with possible coarse neurobehavioral psychiatric disease, such as dementia, stroke, or focal cerebral lesions. When performed, the short Folstein Mini-Mental State Exam (MMSE) is typically used. The authors' research on 45 neuropsychiatric patients compared the MMSE with a new 20-30-minute bedside examination, the Screening Cerebral Assessment of Neppe (BROCAS SCAN). This screens 10 areas: recall, recognition, orientation, organization of thought, concentration, calculation, agnosia, apraxia, speech, and sensory-motor-reflex phenomena. The BROCAS SCAN (total) correlated extremely well with neuropsychiatric prediction, MRI changes, and neuropsychological testing, and distinguished diagnoses, demonstrating construct and face validity. It also accounted for a larger proportion of variance than the MMSE in correlating with these parameters and was more sensitive in mildly cognitive impaired patients. The briefer first section of the BROCAS SCAN, the core SCAN, also showed statistically relevant relationships to age, diagnosis, MRI, and neuropsychiatric prediction.

Adolescent↗
PubMed1989

The undiluted message in psychiatry: is medical rounding valuable?

The present research investigated whether psychiatric inpatients would recall, without distortion, the key components of information presented to them during morning rounds. Over the 4 weeks of the study, the messages of rounding psychiatrists were recorded and then compared with the recollections of 16 subjects recorded several hours later. Analysis showed that undistorted recall of messages occurred significantly more often than distorted recall or no recall. These results suggest that there is a possible value for undiluted messages in medical rounding in the inpatient psychiatric context when given as an adjunct to psychotherapeutic and psychopharmacological interventions.

Humans↗
PubMed1989

Carbamazepine adjunct for nonresponsive psychosis with prior hallucinogenic abuse.

Some patients diagnosed as schizophrenic report persistent polymodal hallucinosis following a period of extensive hallucinogenic drug abuse unrelieved by the usual antipsychotic drugs. In this open study, carbamazepine (Tegretol, an anticonvulsant) was administered to three patients with polymodal hallucinosis which had failed to diminish on antipsychotic drugs alone. All three patients showed a marked to complete reduction in symptomatology.

Adult↗
PubMed1989

Carbamazepine treatment for benzodiazepine withdrawal.

Nine patients were given carbamazepine before rapid discontinuation of benzodiazepines. Most patients had had long-term benzodiazepine treatment and had abused benzodiazepines; five had taken high doses. All patients tolerated rapid discontinuation well and none developed significant withdrawal symptoms.

Adult↗