PubMed Health⌕ Search

Biomedical subjects

V O Osanyintuyi

Publications and source records attributed to V O Osanyintuyi.

5 recordsLinked to original sources
PubMed1995

Hyponatraemia, birthweight and neonatal jaundice.

Cord serum sodium levels were estimated in 96 full term singletons delivered by spontaneous vertex delivery. Thirty-two of these infants had cord serum sodium of less than 130 mmol/L and 64 had cord serum sodium of > or = 130 mmol/L. Serum bilirubin estimated on day 4 of life of the babies demonstrated mean unconjugated bilirubin levels of 105.7 mmol/L (S.D.:87.04) and 89.4 mmol/L (S.D.:66.18) in the hyponatraemic and normonatraemic groups respectively (P < 0.05). The study also demonstrated a higher cord sodium and lower serum unconjugated bilirubin in those babies whose mothers did not receive parenteral fluids. It is suggested that hyponatraemia should be excluded in the aetiology of neonatal jaundice.

Adult↗
PubMed1988

Screening for glucose-6-phosphate dehydrogenase (G-6-PD) deficiency by a simple method.

The methaemoglobin reduction test (MHRT) was used at room temperature (27-32 degrees C) to screen for G-6-PD deficiency. Blood (0.5 ml) was incubated for 4 h. The results obtained were in good agreement with those obtained using the fluorescent screening method (FSM) (P less than 0.01). In the males, there was agreement in 95% of the cases. Most of the differences occurred in the females. It is concluded that since MHRT can be used at room temperature, and since the materials needed are cheap and easy to get and electricity is not essential, most hospitals should be able to use the MHRT method to screen for G-6-PD deficiency.

Adult↗
PubMedDate not supplied

Serum alpha 1-antitrypsin levels in asthmatic children.

Serum levels of alpha 1-antitrypsin (AAT) were determined by an enzymatic assay method in fifty-five asthmatic children and in the same number of controls. The mean AAT level was significantly lower in asthmatics (1.65 mumol/min/ml) than in controls (2.0 mumol/min/ml) (P less than 0.02). A significantly higher proportion of asthmatics than controls (P less than 0.05) had levels below 2.1 mumol/min/ml which is the lower limit of normal, thus suggesting a higher prevalence of partial (heterozygous) AAT deficiency in the asthmatics. There was no relationship between the mean AAT levels and age, duration of asthma or frequency of asthmatic attacks. Although there is some controversy about the relationship between heterozygous AAT deficiency and pulmonary disease, severe (homozygous) AAT deficiency has been linked with emphysema which is also a complication of asthma. There was however, no evidence of emphysema in either the asthmatic child or the control who had no detectable serum AAT. There were three asthmatics whose chest radiographs showed hyperinflation, but had a mean AAT level that was not significantly different from that in those without such changes. Further studies, including phenotype determination in a larger group of asthmatic children, are required in order to determine the prevalence of both homozygous and heterozygous AAT deficiencies which may be risk factors in the development of emphysema and other pulmonary complications of asthma.

Adolescent↗