[Isolation of cellular structures from cultured Treponema pallidum and study of their antigenic properties in complement fixation tests].
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Biomedical subjects
Publications and source records attributed to V O Pozharskaia.
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The structural organization and functioning of parasitic systems are considered in the context of the general theory of systems. By using the parasitic system of an epizootic process of plague as an example, the essence of the concepts of the structural organization and functioning of the systems is determined, and a scheme of a relationship of elements in the trinomial parasitic systems is presented. The mechanism of parasite-host interaction at the molecular, cellular, body's, and populational levels is considered on the basis of the theory of immune-specific wave information in an living organism.
New data on the functional properties of the cell structures of cultured T. pallidum were obtained, which permitted the construction of new more effective preparations for the diagnostics of syphilis. T. pallidum cell walls were used as antigen in the complement fixation test (CFT) and the development of a new enzyme immunoassay system for the determination of IgM and IgG antibodies to T. pallidum with the visual evaluation of results, while T. pallidum cytoplasm was used as sorbent in the immunofluorescence test (IFT-abs) for the serodiagnosis of syphilis. The immunization of rabbits with T. pallidum cell walls increased the titers of positive control sera used in CFT for diagnosing syphilis.