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Biomedical subjects

V P Bersnev

Publications and source records attributed to V P Bersnev.

At least 19 recordsLinked to original sources
PubMed2006

[The diagnosis of cerebral meningiomas at the stage of early clinical manifestation].

Presented are the results of the analysis on efficacy of cerebral meningiomas diagnosis at the stage of early clinical manifestation. The case-history data of 277 patients (95.5%) examined at the early stage of clinical manifestation have been analyzed. Type and frequency of referrals to the doctor at different periods of the disease and their dynamics, the set of curative and diagnostic procedures used for patients' examination during the referrals and timeliness and degree of diagnosing intracranial meningiomas at different stages of examination have been established. Factors responsible for the clinical manifestation of the existing tumor have been determined. Diagnosis of cerebral meningiomas at the stage of early clinical manifestation remains unsatisfactory: 24.6% of patients (68) did not seek medical aid despite the presence of clinical symptoms of the tumor and 40.9% attended the doctor repeatedly. In primary examination, cerebral meningioma was diagnosed in 30.7% of outpatients and in 47.3% of in-patients.

Adult↗
PubMed2004

[Clinical and neurophysiologic aspects of surgical treatment of pharmacoresistant forms of epilepsy].

Surgical treatment of pharmacoresistant forms of epilepsy under neurophysiological monitoring is a key problem studied in A.L. Polenov Russian Neurosurgical Institute (Saint-Petersburg). A summary of long-term studies and main stages of surgical treatment development are presented. The indications and contra-indications, along with basic neurophysiologic strategic and tactic arguments of open and stereotaxic treatment of focal and generalized epilepsy based on neurophysiologic model which determines a role of epileptic focus, epileptic and inhibiting brain systems in spreading and arresting of seizure discharge at each disease stage are formulated. A program of clinico-neurophysiologic monitoring of temporal epilepsy in pre- and intraoperative periods is considered.

Anticonvulsants↗
PubMed2000

L-MYC and GSTM1 polymorphisms are associated with unfavourable clinical parameters of gliomas.

L-MYC and GSTM1 genotypes were analysed in glioma patients (GP) and healthy donors (HD). None of these genes appeared to influence the risk of this disease, however both polymorphisms correlated with unfavourable clinical parameters of gliomas. In particular, S allele of the L-MYC was overrepresented in the relapsed patients (P < 0.05), and GSTM1-null genotype was associated with the advanced tumour grade (P < 0.05). Patients, but not donors, demonstrated frequent combination of SS L-MYC homozygosity with GSTM1(-) variant (P < 0.01 ), as well as a correlation between LL L-MYC homozygosity and GSTM1 (+) genotype (P < 0.05).

Alleles↗
PubMed1999

[L-myc and GSTM1 polymorphism in cerebral glioma].

L-MYC and GSTMI polymorphisms were studied in glioma patients. L-MYC allele frequency in patients (L: 61/114 (54%); S: 53/114 (46%)) and controls (L: 108/204 (53%); S: 96/204 (47%)) was identical. S allele was associated with certain unfavourable clinical features of the disease. In particular, its frequency was 26/42 (62%) in relapse vs. 26/68 (38%) in relapse-free disease (p < 0.05). GSTMI "null" genotype was identified in both patients and healthy donors (48%). GSTMI-deficient genotypes were significantly predominant in patients with grade III-IV gliomas as compared with grade I-II tumors (p < 0.05). Patients, but not donors, frequently revealed a combination of SS L-MYC homozygosity and GSTMI (-) variant (p < 0.01) as well as an association of LL L0-MYC homozygosity and GSTMI (+) genotype (p < 0.05).

Alleles↗
PubMed1995

[Comparative results in gunshot and non-gunshot nerve injuries].

An analysis of clinico-neurological and electrophysiological examinations of 88 patients before and during the operation enabled the authors to establish substantial pathomorphological and functional distinctions of gunshot and not gunshot injuries of the nerves, difference in results of various operative procedures.

Brachial Plexus↗
PubMed1988

[Diagnostic difficulties and possibilities in nerve damage of the extremities].

In 978 patients, clinico-neurological and electrophysiological investigation was performed in order to obtain differential diagnostic tools for the extent of nerve damage. Preoperatively, only clinico-neurological signs of complete or severe conductivity impairment, without electrophysiological investigations, can provide indications to the nerve suturing or neurolysis. Electrophysiological signs of complete lack of conductivity are indications to operation (taking into account the type, duration and level of the trunk lesion), and partial conductivity impairment is a counterindication to surgery.

Arm↗
PubMed1980

[Evoked muscle potentials in severe conduction disorders of injured nerves].

In 175 patients with clinical signs of grave impairment of the conductivity, absence of induced muscular potentials has helped to diagnose full anatomic rupture of the nerve, i.e. a case when resection and junction of the nerve by suturing are necessary. The examination of the induced muscular potentials made it possible to specify the degree to which the continuity of the axons inside the nerve trunk was preserved. The amplitude of the induced muscular potentials was lowered down to 0.01 mV. The speed of the stimulus conduction diminished down to 40.0 +/- 9 m/sec in cases of the median nerve damage: to 44.4 +/- 4 m/sec, if the ulnar, and to 11.1 m/sec, if the radial nerve was damaged.

Accessory Nerve Injuries↗
PubMed1979

[Study of muscle excitability in response to currents of different duration in the diagnosis of nerve injuries].

The "strength-duration" curve was studied in 154 patients in different periods after injury to the median nerve, ulnar nerve or both nerves. The most probable mean values of strength (U) in changes of the duration (t) of the current 1--6, 7--11 months and more than 12 months after injury were obtained by means of the equation U=a0 + a1t +a2t2 by the least squares method. It was established that the excitability of muscles diminishes continuously but persists more than 15 years after total anatomical interruption of the nerve. Absence of electroexcitability of the forearm muscles as a result of ischemia is not a contraindication for nerve suturation. Suturation of the nerve leads to restoration of sensibility and active contractions of the hand muscles. The deviations in the "strength-duration" curve are signs of partial injury to the nerve. It was found that the more the number of deviations in the "strength-duration" curve and the more its left part on the side of the injury resembles the curve recorded from the symmetrical healthy muscle, the more rapidly is the nerve conduction restored and the more rapidly it improves after nonoperative treatment.

Adult↗
PubMed1976

[Skin temperature and the hot water test in the diagnosis of injuries to the median, ulnar and tibial nerves].

In 289 patients with a complete anatomical interruption of the median, ulnar and tibial nerves from 1 month to 2 years following the trauma the author determined the skin temperature in the autonomous zone and in the one of a maximum drop of sensibility. Anesthesia, a temperature drop on the average from 1.4 +/- 0.5--2.2 +/-0.5 degrees C, the absence of skin folds and a pinck color in thermal tests clarify the diagnosis of a complete anatomical interruption of the median or ulnar nerve. In lesions of both nerves, especially in combination with lesions of the arteries, the skin temperature is lower than that in an isolated damage of one of the neves. In most of the patients with an interruption of the tibial nerve the skin temperature in the autonomous zone is higher and there are no skin folds in the autonomous zones in thermal tests. Skin temperature measurements and thermal tests are simple objective methods in the diagnosis of nerve lesions.

Adolescent↗