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Biomedical subjects

V P Boĭkov

Publications and source records attributed to V P Boĭkov.

At least 19 recordsLinked to original sources
PubMed2006

[Comparative assessment of the five-year results of surgical, combined, radiation and chemoradiotherapy in laryngeal cancer (T3N0M0)].

Four modalities of specific treatment for laryngeal cancer were compared in 158 patients. Five-year survival after chemoradiotherapy using cisplatin, 5-FU and bleomycin plus irradiation (65-70 Gy) was 87% versus 69.7; 66.2 and 45.9% after surgical, combined and radiotherapy, respectively. Chemoradiotherapy failed in 22.4%, as compared with 28.9; 31.5 and 41.7% after the alternative modalities, respectively. Organ preservation was used in 30.3% of surgical cases and 58%--in combined treatment group.

Adult↗
PubMed1996

[Autofluorescence diagnosis of malignant tumors of the head and neck].

A new method for diagnosing human malignant tumors is dealt with, which is based on fluorescence of malignant neoplasms and their adjacent normal tissue. To measure the fluorescence spectra, a fiber optic system and a multi-channel optic spectral analyser have been designed. While analysing the resultant spectra, a greater fluorescence excess was observed in the red wave band in the tumors than in normal tissue. Further investigations are required in order to use the method in question in clinical diagnosis.

Biopsy↗
PubMed1987

[Carcinoid of the larynx].

Laryngeal carcinoid with metastases to cervical lymph nodes was observed in a patient of 62. The diagnosis was confirmed by electron-microscopic study. The patient was followed up for 9 mos without any evidence of recurrence and metastases after laryngectomy and fascial envelope excision of cervical fat. The morphologic picture of laryngeal carcinoid is characterized by the presence of the alveolar, trabecular and teniform structures consisting of monomorphic and moderately polymorphic cells. Tubular and rosette-like structures occur. The overlying epithelium is intact. The necrotic foci, as a rule, are absent. Grimelius reaction is positive, argentaffinnic granularity isn't revealed. Electron-microscopic study demonstrates endocrine-type granules. The need for recognition of laryngeal carcinoid is explained by the fact that this tumour form has a more favourable course and prognosis in comparison to cancer.

Carcinoid Tumor↗
PubMedDate not supplied

[Combined treatment of stage III laryngeal cancer with different schedules of radiotherapy and surgery. Evaluation of preventive methods of the treatment of regional areas (cooperative randomized study)].

In 1980-1987, a cooperative randomized study of 363 patients with stage III laryngeal cancer (T1-3N0-1M0) was carried out. In 249 patients tumor was located in the vestibular space and in 114 in the vocal cord area; 78.5% of the patients had no regional metastases (N0) and 21.5% had metastases (N1). Combined therapy was applied to 251 patients, 135 of which were first exposed to radiotherapy and then to surgery and 116 were first exposed to surgery and then radiotherapy. In 71 patients, regional zones underwent preventive treatment (in 24 patients elective radiotherapy and in 47 preventive removal of the cervical fat were used). In 112 patients, the therapeutic protocol was modified due to different reasons (69 patients underwent only surgery and 43 radical radiotherapy). The therapeutic results were assessed in terms of three parameters: incidence of relapses and regional metastases, relapse-free time, and survival. This approach revealed no significant differences in the efficacy of the different protocols of the combined treatment. The 5-year survival rate of the patients with vestibular and cord space tumor was 77.9% and 80.7% respectively, when treated according to the radiotherapy + surgery protocol, and 82.8% and 89.2%, respectively, when treated according to the surgery + radiotherapy protocol. Comparison of preventive approaches showed that the 5-year survival rate increased by 92% as a result of removal of the subcutaneous fat from the neck area.

Combined Modality Therapy↗