Clinical trials were carried out on 55 patients (55 eyes) divided into 2 groups. The main group consisted of 27 patients treated by a therapeutic complex including vitrectomy with ozonized normal saline and the controls (28 pts) were treated by vitrectomy with intravitreal administration of 0.4 mg gentamicin. The diagnosis was made by clinical and laboratory methods. The volume of liquid used in vitrectomy was recorded. Ozonized saline was to be used within the period during which the therapeutic concentration of ozone was retained. Ozonized saline in therapeutic doses is not toxic and in contrast to antibiotics, is characterized by a wide spectrum of effects. Hence, vitrectomy with ozonized normal saline is a new effective method for treating endophthalmitis.

Adult↗

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[The use of different types of explants in the surgery of retinal detachment].

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Culture Techniques↗

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[Deacetylation of chitin under homogeneity].

Chitin isolated enzymatically from Antarctic krill shells was dissolved in aqueous NaOH by freezing and thawing to create homogenous conditions. Deacetylation was performed at room temperature or heating. The degree of deacetylation, molecular weight, and dynamic viscosity of solutions were estimated in chitosan samples. Deacetylation of chitin under homogenous conditions was optimized. Chitosans with molecular weights of 180-220 and 250-300 kDa were obtained from the chitins of Antarctic krill and Northern shrimps, respectively.

Acetylation↗

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[Experimental intraocular introduction of blood serum of patients with endophthalmitis].

Effects of blood serum from patients with endophthalmitis, who systematically received gentamicin at therapeutic dose, exerted on the retina of healthy rabbits were experimentally studied. A moderate toxic effect produced by gentamicin on the retina, when it was administered in the vitreous body of rabbits, was detected yet on day 1 of the experiment. Changes of retinal electrogenesis were aggravating and, beginning from day 7, there were noted profound changes of the functional activity in all retinal layers. According to the results, the blood serum from patients with endophthalmitis, who were systematically receiving gantamicin at therapeutic dose, does not virtually have any negative effect on the functional condition of the retina and can be used for intracavitary administration.

Animals↗

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