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Biomedical subjects

V P Calabrese

Publications and source records attributed to V P Calabrese.

25 records · Page 2Linked to original sources
PubMed1979

Psuedotumor cerebri and insecticide intoxication.

Three patients with headache and increased intracranial pressure had elevated blood, serum, and adipose levels of the organochlorine insecticide chlordecone (Kepone). These patients were among 23 employees who suffered from chronic chlordecone intoxication resulting from industrial exposure. In our three patients, investigations eliminated an intracranial mass or other known causes of psuedotumor cerebri. In all three patients, the capacity for cerebrospinal fluid (CSF) absorption was assessed by graded infusions into the subarachnoid space, and was found to be impaired even when papilledema was minimal.

Adult↗
PubMedDate not supplied

A fatal case of sun exposure in a multiple sclerosis patient.

A 35-year-old woman with a long standing history of relapsing-remitting multiple sclerosis became physically incapacitated by heat-induced muscle weakness while sunbathing and suffered fatal sun exposure. These deleterious effects of increased core temperature on the neurological symptoms have been documented for a half century. Elevation of the patient's core temperature may lead to either transient or permanent neurologic symptoms and signs that predispose to considerable morbidity and mortality.

Adult↗
PubMedDate not supplied

Cerebrospinal fluid lactate levels and prognosis in status epilepticus.

Despite recent advances in the treatment of status epilepticus (SE), the mortality and morbidity associated with this condition remains high. Although the reasons for this excessive mortality are not known, several factors are suspected, including cerebral ischemia, cardiovascular collapse, toxic stimulation by neurotransmitters and hormones, or toxic products of intermediary metabolism. Cerebral lactic acidosis can cause cortical injury and has been shown to occur with seizures in experimental animals and in a limited number of human studies. We determined cerebrospinal fluid (CSF) and plasma lactate in 29 patients with generalized SE of diverse etiology. CSF was obtained within 12 h of termination of clinical seizure activity. The mean CSF lactate for all SE patients was elevated (3.74 +/- 0.31 mM) as compared with that of normal controls (1.60 +/- 0.10 mM) from non-neurologic patients undergoing spinal anesthesia. In patients who died or had a poor neurologic recovery, CSF lactate level was 5.36 +/- 0.58 mM (9 patients), whereas in 20 patients who showed good recovery CSF lactate level was 3.01 +/- 0.22 mM (p less than 0.005). The results demonstrate that SE causes a significant increase in CSF lactate and suggest that the magnitude of lactate elevation may serve as a predictive indicator of morbidity and mortality.

Adult↗