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Biomedical subjects

V P Fedotov

Publications and source records attributed to V P Fedotov.

At least 19 recordsLinked to original sources
PubMed2004

[Genetic and epidemiologic analysis of hereditary diseases of the nervous system in the cities of Volgograd and Volzhskiĭ].

A genetic epidemiological study of hereditary diseases of the nervous system (HDNS) was conducted in the cities of Volgograd and Volzhsky for the first time. In total, 1 323 500 individuals were examined including the populations of Volgograd and Volzhsky (1 012 800 and 310 700 persons, respectively). The prevalence of neurological diseases with autosomal dominant (AD), autosomal recessive (AR), and X-linked recessive inheritance was estimated. These data were compared with the estimates previously obtained for different population of the Russian Federation. A decrease was found in general HDNS load in Volgograd and Volzhsky. The compared populations were shown to differ in a contribution of AD, AR, and X-linked recessive diseases into the HDNS load formation. The possible effect of population dynamics factors on the HDNS load structure is discussed.

Genes, Dominant↗
PubMed2004

[Nozological spectrum of hereditary diseases of the nervous system in the cities of Volgograd and Volzhsky].

A spectrum of hereditary diseases of the nervous system (HDNS) was studied in the cities of Volgograd and Volzhsky. The estimates were obtained for the prevalence of major HDNS groups and individual nosological forms. The populations examined differed in prevalence of this pathology and in contribution of individual diseases and their nosological forms into HDNS load formation. The effect of the population dynamics in Volgograd and Volzhsky on the HDNS prevalence is discussed.

Genes, Dominant↗
PubMed2002

[Diagnosis and principles of complex therapy of sarcoidosis].

The diagnosis and therapy of 87 patients with sarcoidosis admitted to the Central Military Clinical Tubercular Hospital were analyzed. The diagnosis was based on the data of clinicoroentgenologic investigation and histologic examination of the specimen taken from the affected tissue. The differential diagnosis with tuberculosis is obligatory. The complex therapy includes corticosteroids, antioxydants, phytotherapy, physiotherapeutic methods and in some cases plasmapheresis.

Adrenal Cortex Hormones↗
PubMed2001

A new locus for autosomal dominant Charcot-Marie-Tooth disease type 2 (CMT2F) maps to chromosome 7q11-q21.

Charcot-Marie-Tooth disease (CMT) constitutes a genetically heterogeneous group of inherited motor and sensory peripheral neuropathies. The axonal type of CMT is designated CMT type 2 (CMT2). Four loci for autosomal dominant CMT2 have been reported so far. Only in CMT2E, linked to chromosome 8p21, disease-causing mutations in the gene for neurofilament light chain (NEFL) were identified. In this study we report a multigenerational Russian family with autosomal dominant CMT2 and assign the locus to chromosome 7q11-q21. The CMT2 neuropathy in this family represents a novel genetic entity designated CMT2F.

Adolescent↗
PubMed2000

Screening for mutations in the peripheral myelin genes PMP22, MPZ and Cx32 (GJB1) in Russian Charcot-Marie-Tooth neuropathy patients.

Charcot-Marie-Tooth disease (CMT) and related inherited peripheral neuropathies, including Dejerine-Sottas syndrome, congenital hypomyelination, and hereditary neuropathy with liability to pressure palsies (HNPP), are caused by mutations in three myelin genes: PMP22, MPZ and Cx32 (GJB1). The most common mutations are the 1.5 Mb CMT1A tandem duplication on chromosome 17p11.2-p12 in CMT1 patients and the reciprocal 1.5 Mb deletion in HNPP patients. We performed a mutation screening in 174 unrelated CMT patients and three HNPP families of Russian origin. The unrelated CMT patients included 108 clinically and electrophysiologically diagnosed CMT1 cases, 32 CMT2 cases, and 34 cases with unspecified CMT. Fifty-nine CMT1A duplications were found, of which 58 belonged to the CMT1 patient group. We found twelve distinct mutations in Cx32, six mutations in MPZ, and two mutations in PMP22. Of these respectively, eight, five, and two lead to a CMT1 phenotype. Eight mutations (Cx32: Ile20Asn/Gly21Ser, Met34Lys, Leu90Val, and Phe193Leu; MPZ: Asp134Gly, Lys138Asn, and Thr139Asn; PMP22: ValSer25-26del) were not reported previously. Phenotype-genotype correlations were based on nerve conduction velocity studies and mutation type.

Adult↗
PubMed1993

[Increased sensitivity of hypophyseal cells from neonatal rats to bromocriptine and melatonin].

Age-related peculiarities of the bromocriptine and melatonin effect on macromolecule biosyntheses in cultured rat pituitary cells were studied during long-term (3 day) incubation. Bromocriptine (10(-9)-10(-7) M) caused dose-dependent inhibition of DNA synthesis in pituitary cells of neonatal rats, but only in maximal dose (10(-7) M) it decreased significantly this parameter in pituitary cells of adult animals. Melatonin (10(-8)-10(-6) M) caused significant inhibition of DNA synthesis in cultured cells of neonatal rat pituitaries. However, melatonin did not change DNA biosynthesis in pituitary cells of adult rats. The results obtained permit us to suggest certain contribution of dopaminergic tone and melatonin to the control of proliferative activity of rat pituitary in neonatal period of development.

Age Factors↗
PubMed1993

[The possible participation of gap junctions in the realization of the effects of stimulators of secretory processes in the hypophysis].

Sodium butyrate and octanol did not change the basal rate of GH secretion. However, octanol completely and partially suppressed GH release stimulated by thyroliberin and DbcAMP, respectively. Octanol did not influence GH secretion induced by DbcGMP. Besides, octanol did not change significantly basal prolactin release, but this agent blocked secretogenic action of on lactotrophs. The results show the important role of cell-to-cell communication mediated by gap junctions in stimulatory action of thyroliberin and cAMP analogue on GH release from neonatal pituitary cells, as well as in secretogenic action of thyroliberin on lactotrophs.

Animals↗
PubMed1992

[Secretory activity of lactotrophs and its regulation by hypothalamic hormones in primary cultures of pituitary cells of rats of different ages].

Basal prolactin (PRL) secretion and the responses of lactotrophs to thyroliberin, dopamine and somatostatin were studied in the experiments employing primary monolayer cultures of pituitary cells obtained from developing rats of different ages. High responsiveness of PRL-secreting cells to the action of hypothalamic hormones was observed in the group of neonatal rats, although basal PRL release was about two orders lower in pituitary cultures of neonatal rats as compared to the cultures of immature, pubertal and adult animals. The investigation performed could reveal quantitative, but not qualitative differences in the reactions of lactotrophs of various age groups. It is concluded that postnatal development in the rat is coupled with significant changes of basal PRL release and to a lesser extent, with changes of lactotroph responsiveness to hypothalamic hormones.

Age Factors↗
PubMed1991

[Effects of dibutyryl derivatives of cyclic nucleotides on synthesis of total RNA and proteins in cultured fetal rat hepatocytes].

During short-term (6 h) or long-term (24 h) incubation of fetal rat liver cells in primary cultures, 10(-3) M dibutyryl-derivative of cyclic AMP (Bt2cAMP) and sodium butyrate decreased total RNA and protein synthesis. In contrast, dibutyryl-cyclic GMP (Bt2cGMP) at the same dose (10(-3) M) was without significant effect on RNA and protein biosynthesis. During short-term (4 h) incubation 10(-3) M Bt2cAMP and Bt2cGMP stimulated serum albumin production, while sodium butyrate was without effect. In long-term (22 h) incubation only 10(-3) M Bt2cAMP noticeably increased albumin production. The results obtained clearly show that Bt2cGMP, unlike Bt2cAMP, is not able to modify significantly total RNA and protein synthesis in cultured fetal rat liver cells. It is concluded also that the effects of dibutyryl-derivatives of cyclic nucleotides, at least on albumin production, are not mimiebet by butyrate.

Animals↗
PubMed1990

[The characteristics of the clinical manifestations and the pathogenesis of foot mycoses complicated by candidiasis in metallurgists].

Mycologic examinations of patients with mycoses of the soles, working at 5 metallurgical plants in the town of Zaporozhye, have detected T. rubrum in 71.3 percent and T. interdigitale in 28.7 percent of cases. In 110 (18.3 percent) patients C. albicans were isolated from foci of involvement in parallel with Trichophyton. As a rule these patients were engaged in 'hot' shops and suffered from dysfunctions of various vital organs and from metabolic disorders. Mycoses of the soles complicated with Candida infection were characterized by marked exudation and dissemination with symptoms of eczema, intensive itching, efflorescence of the allergic type. High immediate and delayed-type hypersensitivity to administration of Candida antigen was observed in them. Cell-mediated and humoral immune response of these patients was essentially uncoordinated with depression of the T-immunity and nonspecific defense factors as a rule.

Candidiasis, Cutaneous↗
PubMed1990

[Hormonal regulation of the production of serum albumin by cultured hepatocytes of rats during prenatal and postnatal period of development].

The effects of several hormones on the production of immunoreactive serum albumin (SA) were examined in primary cultures of liver cells obtained from rat fetuses on 21-22 days of gestation of from 3-week old rats. Cortisol, bovine insulin and human growth hormone stimulated SA production in both types of liver cell cultures during 20 h-incubation. L-Triiodothyronine (T3; 10(-9)-10(-7) M) weakly stimulated SA production by hepatocytes from the rats, but markedly inhibited it in cultures of fetal rat liver cells in a dose-dependent manner. In contrast, T3 action on total RNA and protein biosynthesis, estimated as the incorporation of labelled precursors into macromolecules, was stimulatory one in both types of cell cultures. It is concluded that hormonal regulation of SA production is similar in cultured liver cells from fetal and early postnatal rats except for the action of T3. The physiological importance of striking developmental change of T3 action on SA production remains to be determined.

Age Factors↗
PubMed1990

[The combined treatment of psoriasis using curative factors from the Sea of Azov].

A total of 319 psoriasis patients were treated at the Interdistrict Rehabilitation Center for Skin Diseases. Multiple-modality treatment making use of therapeutic factors of the Sea of Azov (sea water, liman and sea muds, solar or UV irradiation, mineral water) and (in some cases) drugs was employed. The suggested method of differentiated therapy in summer and autumn-winter has brought a manifest therapeutic effect, was conducive to regression of the clinical symptoms, to normalization of concomitant abnormalities of the gastrointestinal tract, liver, hematologic, biochemical, and immunological parameters. Such therapy resulted in prolongation of remissions, shortening of the treatment terms, and a more benign course of the disease, particularly so after repeated courses administered for 2-4 years.

Adolescent↗
PubMed1990

[The clinico-laboratory evaluation of the efficacy of the external treatment of microsporosis using a 5% mebetizol ointment].

Therapeutic efficacy of external application of 5 percent mebetizol ointment was analyzed in the treatment of 140 patients with microsporosis. The best effect was achieved when such therapy was combined with oral griseofulvin in glabrous skin microsporosis. The effect of treatment of mycosis of the hairy part of the head was less marked. No cases of the therapy intolerance, complications, or recurrences were recorded. Toxic effects of mebetizol on vital organs were not observed. External applications of 5 percent mebetizol ointment permitted cut down of the periods of treatment by 10-15 days, this being a significant economic effect.

Administration, Cutaneous↗