PubMed Health⌕ Search

Biomedical subjects

V P Glukhov

Publications and source records attributed to V P Glukhov.

9 recordsLinked to original sources
PubMed1991

[The role of the adrenoreactive structures of the amygdaloid complex in regulating blood coagulation].

In chronic experiments on male cats the irritation of adrenoreactive amygdalar structures by catecholamines injection through chemotrode was performed. It was shown that these structures took part in the regulation of the blood coagulative system and specificities of alpha- and beta-adrenoreactive structures influences upon different phases of blood coagulation were also discovered.

Adrenergic alpha-Antagonists↗
PubMedDate not supplied

Role of adrenoreactive structures of the amygdaloid complex in the regulation of blood coagulation.

The stimulation of alpha-adrenoreactive structures of the amygdaloid complex, both in isolation and against the background of disengaged beta-adrenoreactive structures, was carried in experiments on male cats in chronic experimental conditions through an implanted chemotrode. It was shown that the alpha-adrenoreactive structures of the amygdaloid complex exert an influence mainly on blood coagulation phases I-II. Blood coagulation phase III changes indirectly through the shortening of phases I-II. The stimulation of beta-adrenoreactive structures of the amygdaloid complex induces the elongation of blood coagulation phases I-III over the duration of the entire experiment. The stimulation of these structures in conditions of the disengagement of the alpha-adrenoreactive structures of the amygdala leads to insignificant changes in phases I-II, after which a hypercoagulation effect is observed. Blood coagulation phase III in these conditions reflects a marked hypocoagulation effect. The data obtained suggest a modulating role of the adrenoreactive structures of the amygdaloid complex in the regulation of the processes of blood coagulation.

Amygdala↗
PubMedDate not supplied

[New approaches to the system regulating the aggregate state of the blood].

It is shown that in the organism there is an adrenoreactive system of the aggregate blood state regulation (ABSR) including alpha- and beta-adrenoreactive structures of hypothalamus, amygdalar complex and peripheral vessels. The ABSR system consists of two subsystems, each possessing specific action. Both subsystems interact in the reciprocal manner by the mechanism of feedbacks and can exert a modulating effect on each other.

Animals↗
PubMedDate not supplied

[The role of the interrelations between adrenoreactive structures of the anterior hypothalamic area and blood vessels in the regulation of blood coagulation].

In chronic experiments on 26 male rats solutions of norepinephrine and isoprenaline were introduced through chemotrode to anterior hypothalamus. These solutions were used either solely or were followed by the blockade of the same-called vessel adrenergic receptors. It is shown that adrenoreactive structures of the anterior hypothalamus realize their action through adrenergic structures of the vessel wall in the process of blood coagulation.

Animals↗
PubMedDate not supplied

[Role of functional interrelationships of the adrenoreactive structures of the amygdalar complex and vascular walls in the regulation of blood coagulation].

The chronic experiments on 24 male cats were carried out to study the influence of changes in functional interrelations between alpha- and beta-adrenoreactive amygdalar structures and corresponding receptors of vascular wall upon haemostatic system. It is shown that activation of alpha-adrenoreactive structures causes the hypercoagulative effect and that of beta-adrenoreactive receptors--the hypocoagulation activation. The central adrenoreactive structures realize their regulative influences through corresponding peripheral adrenoreceptors of the vascular wall.

Amygdala↗
PubMedDate not supplied

[The role of adrenergic structures of the posterior hypothalamus in the regulation of the blood coagulation system functions].

Under conditions of chronic experiment, the stimulation of alpha- and beta-adrenergic structures of the posterior hypothalamus was performed. The same procedure was repeated after inactivation of these structures. The results of experiments have shown a specificity of the influence of alpha- and beta- adrenergic structures upon the separate blood coagulation phases and the heterogeneity of those structures distribution in the posterior hypothalamic region.

Animals↗
PubMedDate not supplied

[Effect of the adrenoreactive structures of the anterior hypothalamus on blood coagulation].

In the chronic experiment stimulation of alpha- and beta-adrenoreactive structures of the anterior hypothalamus by adrenolytic substances is carried out before and after the blockade. The results of the experiments show specificity of the influence of alpha- and beta-adrenoreactive structures of the anterior hypothalamus on different phases of the process of blood coagulability.

Animals↗
PubMedDate not supplied

[An athrombogenic material based on modified polyethylene].

An athrombogenic material, exhibiting selective proteolytic activity, was developed. The material was obtained after modification of polyethylene by means of the polymer complex containing polyacrylic acid and E-caprolactam. The modified polyethylene was treated with thionyl chloride and then it was maintained in the solution containing streptokinase or urokinase. The athrombogenic material exhibited fibrinolytic activity within 15 days; its athrombogenic properties were studied in vitro.

Acrylic Resins↗