Biomedical subjects
Publications and source records attributed to V P Golub.
The paper gives a review of present-day drugs effective against malaria, provides the result of a clinical trial of melloquine, fansidar, fansimeph, chlorochine in diverse malaria forms. The choice of the drug should be individual, basing on the disease severity, form and resistance of tropical malaria causative agent.
The authors treated helminth infestation in 856 patients who have arrived to Russia from tropical countries. Early diagnosis and treatment of helminthiasis in such patients reduce their susceptibility to other diseases in the course of relevant adaptation to new climatic conditions. The authors point to high efficacy of the drugs mebendazol, albendazol, medaminol (against ancylostomiasis, ascariasis, trichocephaliasis), praziquantel (against schistosomiasis and hymenolepiasis).
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The authors considered different views of investigators on the diagnostic antibody titre level in the microagglutination test (MAT) in leptospirosis of man and animals. Some of them took into consideration MAT in low titres (1:10-1:20), and others - in high only (1:400, 1:1000), which gave no possibility to assess the state of leptospirosis morbidity. The authors suggest that the assessment of the level of the titres in single and repeated studies should be approached differentially. In single examination 1:100 and over should be considered as a positive MAT titre for man, 1:200 and over - for cattle, 1:20 and over - for swine, and 1:20 and over for murine rodents. In repeated investigations any level of the titre in case of its dynamics should be taken into consideration.
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