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Biomedical subjects

V P Kharchenko

Publications and source records attributed to V P Kharchenko.

At least 19 recordsLinked to original sources
PubMed2001

[Value of bone densitometry in the determination of vertebral mineral density in participants of the clean-up after Chernobyl accident].

Scanning osteodensitometry helped to study mineral saturation of lumbar vertebra in individuals who liquidated Chernobyl accident consequences. Bone mineral density appeared to depend on radiation dose obtained by the examinees. High risk of osteoporosis revealed in the examinees who participated in the liquidation in 1986. The authors stress that the examinees should be covered by the skeletal state monitoring possible only with osteodensitometry. The article justify that biphotonic scanning osteodensitometers are expedient in Health Care Centers for individuals who liquidated Chernobyl accident consequences.

Absorptiometry, Photon↗
PubMed2000

[Program for the thorough complex examination of individuals who liquidated the Chernobyl power accident consequences].

A program for thorough complex examination of individuals who liquidated Chernobyl power accident consequences provides objective diagnostic information and early diagnosis of both general and oncologic diseases. The program covers examination in regional Medical Centers giving highly qualified medical care for the liquidators. Regional and county hospitals can participate in the program, concerning also individuals exposed to radiation during other radiation accidents.

Adult↗
PubMed2000

[The role of computerized tomography in the diagnosis of primary lung cancer].

A CT-examination of 87 patients with various types of central cancer of the lung was carried out. Computed-tomography scanning is a highly-sensitive method of radiodiagnosis which detects respiratory system lesions, stage, predominant area of involvement and condition of adjacent tissues. On the basis of CT-related features of tumor, type and stage can be identified to choose optimal therapy and follow-up.

Diagnosis, Differential↗
PubMed2000

[Postoperative computerized tomography of thoracic organs in lung cancer patients].

The report discusses the data on the complex radiation examination of 40 lung cancer patients at different stages of postoperative follow-up. Standard X-ray procedures and CT of thoracic organs were carried out. Considerable advantages offered by CT were recorded in the assessment of the pleural cavity, the remaining part of the lung and mediastinal organs. CT evidence played an important role in making differential diagnosis of relapse and other postoperative changes.

Adult↗
PubMed2000

[Experience with and perspectives of an extended radical regimen of radiotherapy for Hodgkin's disease with prophylactic irradiation of the liver and the lungs].

The end-results of extended radical radiotherapy for stage II-III Hodgkin's disease with apparent factors of risk of relapse in the lung and/or liver are presented. The procedure included prophylactic irradiation of both organs. Ten-year relapse-free survival in the lung-irradiation group was 85.9%, overall 10-year survival--94.0%; the liver-irradiation group--90.0 and 94.7%, respectively. Preventive irradiation was shown to significantly decrease the influence of such risks as extended lesions of the mediastinum and spleen. Relapse in the lung was recorded in one case (1.6%) only, with no tumor progression defected in the liver. Significant increase in 5- and 10-year relapse-free survival was established in the lung-irradiation group, as a result of a comparison of the study group and that of controls who showed characteristic signs of intrathoracic risk. Significant difference in overall survival was recorded for the first three years only. As far as the liver-irradiation factor is concerned, the rise in both categories of survival was significant for the 10 years. It is suggested that patients with stage II-III Hodgkin's disease receive prophylactic irradiation whenever they reveal significant signs of risk of relapse in the lung and/or liver.

Adult↗
PubMed2000

[From a mammographic station to the organization of the Federal Mammologic Center].

The history of radiation application for breast cancer diagnosis in Russia is illustrated by an experience gained at the Center. It was concerned with designing specialized X-ray equipment as well as development of Standards to be used at mammographic stations. Teaching programs were devised for training X-ray diagnosis specialists with all necessary qualification to operate high-tech equipment of a mammographic station and to use a wide range of radiation and invasive procedures.

Allied Health Personnel↗
PubMed2000

[Some prognostic factors in the combined therapy of locally advanced breast cancer].

A relationship between the dynamics of growth and pathological response of tumor cells and the number of neoadjuvant chemotherapy courses was established. As a result, there was no correlation between increase in overall and disease-free survival, on the one hand, and stage, on the other. An interval between neoadjuvant chemotherapy and surgery longer than 4 weeks had a negative effect on overall tumor response and duration of disease-free period.

Adult↗
PubMed2000

[Role of induction chemo- and radiotherapy in the treatment of locally advance breast cancer].

336 patients with locally-advanced breast cancer underwent neoadjuvant chemotherapy or chemoradiotherapy. Increase in T- and N-indices (change of stage after neoadjuvant chemotherapy) proved an important prognostic factor. Survival rates correlated with clinical effect and dropped as it diminished. This tendency was clear in both groups. There was no relationship between stage and overall and disease-free survival rates at early stages but later they declined as T- and N-indices decreased.

Adult↗
PubMed2000

[Correlation of clinical effect, pathological response of tumor cells and the end results of combined treatment of locally advanced breast cancer].

A correlation was established between the end-results of neoadjuvant chemotherapy for locally-advanced breast cancer and pathological response of tumor cells. Also, the end-results correlated with CR or PR and pathological response. Only a small proportion of patients with tumor progression were registered as stage III or IV of pathological response (0.6 and 0.8%, respectively).

Adult↗
PubMed1999

[Computerized tomography of solitary lung metastasis].

Experience has pointed to a rather low potential of traditional procedures of roentgenography and tomography in detecting small foci (ca. 4-5 cm in dia.). Metastases are often not seen in the shadow of the ribs, diaphragm and cardio-vascular complex. X-ray computed tomography (CT) is a method of choice for early diagnosis and further tracking tumor process in the lung. Superior spatial resolution offers complete summation-free visualization of the lung parenchyma. Provision of more data, including information on "occult" pathology in the lung, is instrumental in confirming or rejecting diagnosis of solitary tumor.

Adult↗
PubMed1999

[Results of combined treatment of patients with rectal cancer using a single preoperative radiotherapy dose of 7.5 Gy].

The results of 3-year combined and surgical treatment of 173 patients with rectal tumors are discussed. Single dose of 7.5 Gy was administered to 83 patients on the eve of radical surgery. Ninety patients in control received radical surgery alone. One-, two- and three-year radical cure rates in the study group were higher by 22.9, 21.2 and 29.3%, respectively, while 3-year recurrence-free survival in the same group was 2.7 times that in the surgical patients.

Adult↗
PubMed1999

[Single preoperative radiation exposure for stage II breast cancer].

The efficacy of different combinations of radiotherapy and mastectomy after Madden was compared in 411 patients with stage II breast tumors. The least likelihood of local reccurence (4.5 +/- 1.3%) was recorded after single exposure before mastectomy and with/without adjuvant irradiation of the regional lymphatics (group I); it appeared 1.5 times as high (7.0 +/- 2.1%) after mastectomy + postoperative irradiation (group II) while the highest frequency (14.8 +/- 5.4%) was registered after surgery alone (group III). Relapse-free 10-year survival was observed in 63.5 +/- 4.7 (group I), 77.4 +/- 4.6 (group II) and 46.2 +/- % (group III), respectively, the difference between group I and II being significant. Therefore, postoperative radiotherapy in conjunction with mastectomy (Madden) should be recommended for stage II breast carcinoma when the breast cannot be salvaged.

Breast Neoplasms↗
PubMed1999

[New trends in the radiodiagnosis of extensive malignancies of the maxilla and nasal cavity and paranasal sinus mucosa].

Application of computed (CT) and magnetic resonance tomography (MRT) provided means of precise sitting of tumor and identifying boundaries of adjacent tissue involvement. The study established certain characteristics of CT detection of bone damage. It also showed MRT superiority in visualizing the soft-tissue component of neoplasm and distinguishing between tumor tissue and concomitant secondary inflammation.

Adult↗