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Biomedical subjects

V P Konev

Publications and source records attributed to V P Konev.

17 recordsLinked to original sources
PubMed1999

[On the damaging mechanism of mixed wood dust].

The authors showed new immune and morphologic phenomenon--toxic lymphoinhibition--mixed wooden dust (wood laminate, plywood) induces decrease of circulating pool of lymphatic elements and increases mitotic activity in T-dependent zones of central and peripheral lymphatic organs. Pine dust used in experiments and having antigen effects of highly molecular substances activates macrophages and moderate functional stress of T-immunity. With this, leukocyte and lymphocyte counts grow, qualitative and quantitative parameters of phagocytosis increase as well.

Animals↗
PubMed1991

[Morphological and immunological comparisons in epilepsy].

Morphological and immunological assays were employed to examine 18 epileptic patients and 40 Krushinskiĭ-Molodkina rats undergoing subconvulsive and convulsive acoustic stimulations. After multiple audiogenic epileptiform convulsive fits the epileptogenic areas of the brain of epileptic patients (biopsy material) and the neocortex of the sensorimotor area, amygdaloid complex and hippocampus of rats manifested vascular alterations in the form of chronic or subacute vasculitis. The changes revealed in the ratio of B and T lymphocytes in the peripheral blood of the epileptic patients in combination with pronounced stimulation of cellular and humoral immunity responses to antigens of homologous and autologous brain extracts, more well-defined in marked inflammatory process, may attest to the immune genesis of endo- and perivasculitis.

Acoustic Stimulation↗
PubMed1990

[Status of the myocardium and heart valves in funnel chest].

Examinations of 70 patients with keeled deformation of the chest (KDC) have revealed signs of connective tissue dysplasia in all the examinees, as well as heart rhythm and conduction disorders. Echography has shown ventricular and atrial septal defects, mitral valve prolapse, dilatation of the aortic root, tricuspidal valve prolapse, abnormally located chorda. The development of KDC in the presence of external connective tissue stigmata, involvement of the cardiovascular system, changed dermatoglyphic pattern of the palms and fingers (as evidenced by dermatoglyphic analysis), as well as findings of histologic examinations of the cartilage removed in the course of thoracoplasty may indicate a generalized abnormality of the connective tissue in this patient population and KDC may be regarded as one of its manifestations.

Abnormalities, Multiple↗
PubMed1987

[Pathogenetic and immunological characteristics of different forms of the Salmonella typhi carrier state].

Infectious granulomas with macrophages containing Salmonella typhi have been detected in the immune organs of the intestine of typhoid patients by means of morphological investigation techniques, immunofluorescent and electron microscopy. This suggests that typhoid granulomas form the basis of S. typhi primary carriership complicated by the relapses of this infection in cases of weakened cell-mediated immunity, which is proved by a decrease in the level of T-lymphocytes and by increased leukocyte migration index in relapses of typhoid fever and in S. typhi primary carriership. At the same time, the formation of S. typhi secondary carriership occurs in the process of the colonization of the altered organs and tissues of the body by S. typhi. This secondary carriership differs from the primary one by a number of pathogenetic signs. The detailed characterization of these two forms of S. typhi carriership is presented.

Bacteriuria↗
PubMed1976

[Study of delayed hypersensitivity in experimental tick-borne encephalitis].

Experiments were conducted on albino mice. With the aid of the test of inhibition of splenocyte migration in the agar medium it was shown that the tick-borne encephalitis virus caused the state of hypersensitivity of delayed type (HDT) expressed from the 3rd day after the infection and persisting up to the appearance of the clinical signs of the disease; in latent infection the HDT state persisted for a period of up to 50 days (observation period). At the same time the experimental animals displayed a weak splenocyte sensitization with the brain tissue chiefly observed in cases of an acute infection and expressed inconstantly in the latten course of tick-borne encephalitis.

Animals↗
PubMedDate not supplied

[Radiation diagnosis of uncomplicated compression spinal fractures in children].

Experiments on rabbits compared the X-ray, morphological, and magnetic resonance imaging of compression fractures of the vertebral body. Edema of the bone marrow of the vertebral body was ascertained to be a basic morphological substrate that evokes a modified MR signal. The data on 178 children with suspected compression fracture of the vertebral body were used to consider the potentialities of MRI and X-ray study in this pathology. The MRI semiotics of uncomplicated compression fractures of vertebral bodies is presented. The sensitivities of MRI and spondylography in the diagnosis of compression fractures of vertebral bodies were 100 and 62.5%, respectively.

Adolescent↗
PubMedDate not supplied

[The conservative treatment of acute hematogenous osteomyelitis in children].

Radioisotopes were used to study the water spaces of the bone and bone marrow in 47 dogs with a created model of acute osteomyelitis. By the 3rd-5th day of experimental osteomyelitis sharp hyperhydration of the bone marrow and bone proper was revealed which was caused by a 2.5-2.8-fold increase of the volume of intercellular fluid in the zone of the affection, leading to circulatory disorders and necrosis. Dehydration of the tissues is accomplished by inflicting numerous percutaneous osteoperforations (NPO) with Kirschner's wire. The osteoperforations are made not at random but in a regular manner through both walls of the bone in two interperpendicular planes. Circulation in the zone of the affection is restored in this case and osteonecrosis in prevented. Conservative methods of treatment of acute hematogenous osteomyelitis were developed according to the stage of its development and were applied in 168 patients whose ages ranged from 20 days to 14 years; in 75% of patients who were admitted in the early stages of AHO the disease took and abrupt course. In patients with neglected forms of AHO three-fourfold infliction of NPO in the subacute stage produced a stimulating effect on reparative regeneration in the zones of osteonecrosis and the forming sequestra.

Acute Disease↗
PubMedDate not supplied

[Preoperative plombage of damaged bronchi in children with bronchiectases using a biopolymeric compound for cupping endobronchitis].

The authors discuss their experience in the use of a biopolymeric composition of a biological glue KL-3 and an antiseptic for preoperative filling of bronchiectatic cavities in 28 patients with bronchiectases. The filling is performed before the operation during bronchoscopy conducted under anaesthesia. As a result endobronchitis is relieved, the time needed for preoperative management is shortened, and the number of possible postoperative complications is reduced to minimum.

Adolescent↗
PubMedDate not supplied

[Ultrastructural pathology of the lymph nodes in tick-borne encephalitis].

Lymph nodes of humans and experimental animals with tick-borne encephalitis (TBE) were studied using electron microscopy. TBE virus reproduction occurred in macrophages, reticular and plasma cells. Severe organelle destruction was found in the above cells and lymphocytes. The results suggest that macrophage, reticular and plasmatic cell death is due to the virus reproduction, while lymphocyte death is due to the toxic effect. It is evident that the outcome is determined by pathological process in lymphoid organs.

Animals↗
PubMedDate not supplied

[The morphogenesis of tick-borne encephalitis in light of the new data on virus replication].

The analysis of the RNA virus spread of tick encephalitis in the course of infection has been performed. The virus RNA is detectable first, (as early as one day after the infection) in the lymph nodes. Later it is retained in the cells of T-dependent areas. Viral RNA is also the first to be detected in the vascular structures and ventricular system of the brain. The correlation between the time of the viral RNA replication and specific initial damage in the lymphoid tissue and central nervous system is established. The question is raised on the role of the lymphocyte recirculation in the spread of the virus in the body.

Acute Disease↗