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Biomedical subjects

V P Kulagina

Publications and source records attributed to V P Kulagina.

At least 19 recordsLinked to original sources
PubMed1983

[Characteristics of the vascular reactions of rabbits to prolonged stimulations in experimental atherosclerosis].

The constrictory reactions to long electrostimulation of renal, pulmonary femoral arteries and distal aorta segments of intact rabbits getting 200 mg/kg of holesterine during 4-12 months have been compared. It has been established that all artherosclerotic vessels exhibit higher initial amplitude of constriction using as indicator of phasic reactions. the tetanus stability increases, that expresses in longer conservation of initial constriction amplitude on relatively high level; this is evidence of vessels capacity to long tonic reactions. These changes of aorta and pulmonary vessels were more distinct.

Animals↗
PubMed1981

[Vascular reactivity changes in chronic emotional stress of hypothalamic origin].

The vessels of rabbits undergoing a long irritation of the negative emotional zones of the hypothalamus have shown a tendency to increase a constrictive reaction in response to the quantitatively dozed electrostimulation of the vessel walls. This is expressed in the decrease of the range of the stimulation parametres which cause the weakening reaction during 10 days of emotional stress, and in showing only a constrictory reaction to all the parameters of stimulation during a 4-month stress.

Animals↗
PubMed1980

[Effect of indomethacin on cyclic nucleotide metabolism and vascular reactivity in rats].

The content and metabolism of cyclic nucleotides in the aorta as well as contractility were studied in rats given different doses of indometacin. High doses of the drug (5 mg/kg) favored an abrupt decrease in cAMP and cGMP levels in the aorta and did not essentially affect vascular response to electric stimulation. Low doses of indometacin (2 mg/kg), particularly when coupled with salt load, resulted in the decreased cAMP/cGMP ratio and in the potentiation of vasoconstrictor responses. It has been demonstrated that the reduced proportion of cAMP in cyclic nucleotide metabolism is related to the activation effect of indometacin on cAMP-phosphodiesterase activity. The role of the prostaglandin-cyclic nucleotide system in the vascular tone control is discussed.

2',3'-Cyclic-Nucleotide Phosphodiesterases↗
PubMed1979

[Role of calcium in the mechanism of the change in vascular reactivity under the action of reserpine].

Reserpine induces an appreciable reduction of the calcium content in the segments of the distal aorta and rabbit femoral arteries incubated in a saline. These changes develop simultaneously to those in the reaction pattern of the vascular segment to direct electric stimulation (decline of constrictor responses and their subsequent replacement by relaxation). It is postulated that the decreased calcium content in the vascular wall may be one of the causes of altered vascular reactivity.

Animals↗
PubMed1979

[State of the vascular wall in experimental hypertension induced by the administration of indomethacin in combination with a saline drink].

It is shown that various types of vessels (elastic, musculo-elastic, and muscular) possess initially different capacity for synthesizing and destroying prostaglandins. Under the effect of indomethacin and salt load considerable changes occur in the synthesis and metabolism of prostaglandins and the closely related system of cyclic nucleotides in the vessels of experimental animals. The character of these changes suggests the predominance of constrictive vascular reactions, which was confirmed by the results of functional tests on segments of the aorta and femoral arteries. It was shown also that the walls of small arteries of different organs, the kidneys in particular, undergo marked structural changes resulting in their thickening and narrowing of the lumen. These functional and structural changes may underlie the increase in peripheral vascular resistance and be the principal pathogenic mechanism of hypertension.

Animals↗
PubMed1978

[Change in the reactions of isolated vascular segments to electric stimulation under the influence of inderal].

It is shown that under the effect of inderal the relaxation of isolated vascular segments in response to electric stimulation is replaced by their contraction. In the event of initial contractile reactions these are noticeably potentiated. The conditions of the experiment do not allow the effect observed to be explained by the block of specific beta-adrenergic receptors by inderal. Taking into account the data on the effect of inderal on the intracellular biochemical processes, the authors presume that one of the intimate mechanisms of changes in the vascular effects due to inderal are alterations in the content of intracellular calcium.

Animals↗
PubMed1978

[Change in the reactions of isolated vascular segments under the action of hypotensive agents].

It was shown that reactions of isolated vascular segments to electric stimulation changed in character under the effect of reserpine, ornid, benzanidine, and aldomet. Replacement of contraction by relaxation is characteristic of all hypotensive agents. This is revealed on preparations which respond initially by equivocal reactions (relaxation and contraction) depending on the intensity of the stimulation. The replacement of the sign of the reaction is marked by certain peculiarities in the case of each agent. The possibility of contraction is maintained only in response to a high dose of stimulation on condition that benzanidine and aldomet are administered. Under the effect of reserpine and ornid, initially unequivocal reactions are replaced at first by two-phase reactions (contraction then relaxation) and then by single phase (relaxation); under the effect of benzanidine and aldomet they are sharply weakened.

Animals↗
PubMed1977

[Degree of vascular tonus as a factor of changes in the reactivity of the smooth muscle structures of the blood vessels].

The activeness and functional orientation of the responses of isolated vascular segments to electric stimulation depends on the initial tonic tension. A relatively low degree of extension of the preparations corresponding to a low intravascular pressure creates a tendency towards a response in the form of relaxation. Stimulations of the same intensity cause contractions against the background of a more significant extension of the preparations observed in cases of high pressure. The constrictive effects occuring against the background of significant vessel extensions are interpreted as a manifestation of inadequate responses, similar to the hyperreactivity noted in hypertension.

Animals↗