Biomedical subjects

V P Kulazhenko

Publications and source records attributed to V P Kulazhenko.

17 recordsLinked to original sources

PubMed1989

[Pathology of amniogenesis in the early prenatal period of human development].

Morphological and, in a number of cases, cytogenetical investigation has been performed in 420 intact embryonal sacs and in embryos 7-8-week-old, obtained at spontaneous abortions (272) and at tubal pregnancy (148). Among these cases 202 (48.1%) intact empty embryonal sacs, 75 (17.9%) embryos with panorganodysplasia, 25 (6%) embryos with isolated developmental defects and 118 (28%) phenotypically normal embryos have been revealed. Pathology of amniogenesis such as aplasia or hypoplasia of the amniotic cavity is noted in 136 (32.4%) cases. Among 75 embryos with panorganodysplasia anomalies such as hypoplasia of the amniotic cavity in combination with a partial extra-amniotic++ position of the embryos in exocelom (10.7%), aplasia (5.3%) or hypoplasia (17.3%) amniotic peduncle is present in 43 (57.3%) observations. Out of 40 such cases at spontaneous abortions, cytogenetically investigated, in 27 (67.5%) chromosomal disorders (tetraploidy, triploidy, autosomal trisomy and monosomy) are revealed. Aplasia and hypoplasia of the amniotic cavity are considered as pathology of histogenesis at the tissue stage of the early human ontogenesis, that most evidently occurs as a result of asplasia, destruction or anomaly of embryoblast during the first phase of gastrulation on the 7th-11th day of the intrauterine development.

Abortion, Spontaneous↗

PubMed1984

Pancreas annulare in human embryos.

2 cases of pancreas annulare with duodenal stenosis were found among 3,307 induced abortuses of 5-12 weeks where the pancreatoduodenal area was available for examination. This corresponds to a 0.06% incidence, greatly exceeds the occurrence of the anomaly in neonates and suggests partial prenatal elimination of embryos with pancreas annulare and duodenal stenosis. Microscopic examination of serialed embryonic sections gives evidence of (1) the origin of the ring from the ventral anlage; (2) the underdevelopment of the ring material, which later may cause fibrosis of the annulus, usually observed in neonates; (3) the origin of duodenal stenosis in case of pancreas annulare till 8 weeks of fetal life; (4) the development of such stenosis not only due to atrophy of duodenal segment, resulted from compression by the pancreatic ring, but also due to anomalous differentiation of intestinal segment, the cause of which may be the disturbance of morphogenetic correlations.

Adult↗

PubMed1984

Atresia, stenosis and duplication of the gastro-intestinal tract: consideration of their origin.

Malformations of the intestinal tube were studied in 220 infants and in 15 human embryos. Comparison with data in the literature allowed that atresias, stenoses and duplications of the gastrointestinal tract result from some primary morphogenetic disturbance in early gestation more often than from a failure of recanalization, interference with blood supply in fetal life, or from enteritis or peritonitis. This is based on the association of these defects with chromosomal abnormalities (trisomies, partial monosomies, etc); association with malformations which cannot be explained by secondary lesions; the finding of oesophageal stenosis in 6 week-old embryo prior to the stage of epithelial proliferation; the lack of vascular disturbance in cases of the "apple-peel" syndrome and persistence of intramural ganglia in affected segments of bowel.

Chromosome Aberrations↗

PubMed1982