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V P Lynch

Publications and source records attributed to V P Lynch.

11 recordsLinked to original sources
PubMed2000

Mediastinal endodermal sinus tumour: surgical role in chemotherapy resistant cases.

We report two cases of aggressive mediastinal endodermal sinus tumours (EST) detected incidentally on a chest radiograph. The patients were being investigated for minor chest complaints. After three courses of cisplatin-based chemotherapy the tumour marker levels declined. However, the tumour size continued to increase. Complete surgical removal was possible in one case and significant reduction in tumour mass was achieved in the other. Reduction in the viable, tumour tissue load made the residual tumour sensitive to postoperative chemotherapy. It is important to be aware of endodermal sinus tumours refractory to chemotherapy which may require early surgical intervention.

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PubMed1970

Barrett's esophagus: congenital or acquired? An experimental study of esophageal mucosal regeneration in the dog.

The mucosa was removed from the distal esophagus in 35 dogs divided into three groups according to the presence or absence of gastroesophageal reflux and gastric hypersecretion. Partial or complete re-epithelization of the denuded segment by columnar mucus-secreting cells took place. Re-epithelization by squamous epithelium predominated in preparations with a competent inferior esophageal sphincter, while total or nearly total replacement by columnar cells characterized those preparations with gastroesophageal reflux and gastric hypersecretion. Peristalsis persisted in the operated portion of the esophagus as disclosed by esophageal manometry, although contractions were sometimes repetitive and prolonged. Measurement of potential difference was useful in monitoring the re-epithelization process. These experiments support the concept that the columnar-lined distal esophagus ("Barrett's esophagus") may be an acquired condition in which squamous epithelium destroyed by gastroesophageal reflux is replaced, through creeping substitution, by columnar cells of gastric or junctional origin.

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