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Biomedical subjects

V P Morozov

Publications and source records attributed to V P Morozov.

At least 19 recordsLinked to original sources
PubMed1992

[Physiological significance of gastroduodenal blood flow and possibilities of its regulation by drugs].

The authors review the role of the gastroduodenal blood flow as a factor ensuring the secretory activity and protective properties of the gastric mucosa. The possibilities of its pharmacoregulation are also reviewed. It has been shown that the decrease of the gastric blood flow in experimental hemorrhagic shock, extravasal celiac artery stenosis, effects of indomethacin, vasopressin, etc. leads to ischemic injuries to the gastric mucosa accompanied by serious morphological and functional disturbances. The pathogenetic aspects of ischemic injuries to the stomach and duodenum are confirmed by the results of clinical examinations of patients with compression celiac artery stenosis and peptic ulcer. It has been noted that in these patients, the tissue blood flow in the mucosa in considerably decreased in the area of ulcerous defect. The lowering of the content of total phospholipids and changes in their composition were also observed both in relapse and after healing. Out of agents that improve peripheral circulation, propranolol, tavegil combined with cimetidine, trimin appeared most potent. These drugs regulate metabolic processes in gastric tissue, normalizing blood flow, reducing the content of histamine, serotonin, lipid peroxidation products, raising the level of total phospholipids and pepsin.

Animals↗
PubMed1992

[Lipid peroxidation in the blood and tissues of patients with peptic ulcer].

Investigation of 67 patients with peptic ulcer revealed a reliable activation of lipid peroxidation processes both in the blood of the patients and in the mucous membrane in the area of the ulcer location immediately. The activation of lipid peroxidation resulted in a decrease in the contents of phospholipids in the biological membranes of the mucosa cells. The alterations revealed occurred in the presence of inhibition of the antioxidant system of the body. The authors proved the efficacy of the use of antioxidant formulations and ultraviolet irradiation of the blood in the treatment of patients which resulted in acceleration of the ulcer cicatrization and the reduction of the inpatient period as well as the improvement of surgical results.

Adult↗
PubMed1990

[A decrease in the activity of the nucleolar organizers of the gastric and duodenal mucosal cells in peptic ulcer patients].

Silver plating of nucleoli was used to study the activity of nucleolar organizers (NO) in the cells of one-layer prismatic epithelium of the gastric and duodenal mucosae. The activity of NO was established to be lowered in patients suffering from ulcer disease and in patients with compression stenosis of the celiac trunk, which may point to the impairment of protein synthetic processes in the cells. Factor of ischemia as the most probable cause of the enumerated changes is under discussion.

Duodenitis↗
PubMed1990

[Substantiation of differential approach to surgical treatment of duodenal ulcer].

An examination of 395 patients with ulcer disease of the duodenum was made. The authors have developed a program of examination of patients with ulcer disease. In addition to traditional methods it includes such methods as intragastric pH-metry in the body and antral part of the stomach, measuring tissue blood flow in the wall of the stomach and duodenum, investigation of parameters of local resistance of the mucosa, medicamentous tests. The possibility to predict curative effects of surgical procedures is discussed.

Adult↗
PubMed1990

[Improving the reposition of fragments in transosseous osteosynthesis].

As the practice of perosseous osteosynthesis has demonstrated, it is rather difficult to achieve a high accuracy of reposition using a closed technique. The authors offer the simplest and a biomechanically advisable reposition system of the compression and distraction apparatus. The use of such technique proves its efficacy and advantages. The achievement of a high accuracy of reposition and rational fixation of the fragments has allowed for an abrupt reduction in the treatment terms and costs and to improve its quality.

Adult↗
PubMed1989

[Vascular mechanisms of disorders of rheological properties of the blood in patients with myocardial infarction].

The contribution made by vascular factors to impairment of blood rheological properties was demonstrated on the basis of examination of 65 apparently healthy persons by using a vascular occlusion test. The vascular endothelium showed a decrease in fibrinolytic, anticoagulant, antiaggregatory activities. The new term "hemorheological tolerance to vascular occlusion" was proposed to use. A number of quantitative and qualitative indices for normal hemorheological tolerance were identified. The paper provides data on the frequency of particular mechanisms responsible for its decrease. It also emphasizes that the knowledge of the mechanisms of vascular impairments makes it possible to choose a combined drug therapy for myocardial infarction in a differential fashion.

Adult↗
PubMed1989

[Blood flow in the gastric and duodenal mucosa in peptic ulcer].

By means of a polarographic method, the decrease in the rate of blood flow in the gastric and duodenal mucosa at the period of exacerbation of ulcer disease, and its normalization at the period of ulcer healing were revealed. The role of the impaired blood supply of the mucosa in ulcer formation is discussed.

Adult↗
PubMed1984

[Method of surgical intervention for compression stenosis of the celiac trunk].

Experience with the surgical treatment of 265 patients with a compressive stenosis of the celiac trunk has been analyzed. Stenosis of the celiac trunk is known to be a cause of ischemic abnormalities of the stomach, duodenum, pancreas. Decompression of the celiac trunk is an effective method of treatment of the ischemic disease of digestion organs resulting in better organic blood circulation and involution of the appearing pathologic processes. In a number of patients there appeared symptoms for associated interventions due to complications of ischemic gastroduodenal ulcers or concomitant diseases. Excellent and good remote results were noted in 79,6%, satisfactory--in 16,7%, unsatisfactory--in 3,7%.

Celiac Artery↗
PubMed1981

[Visceral circulatory state in experimental stenosis of the celiac trunk].

Considerable disturbances of the visceral blood circulation have been found to occur in stenosis of the celiac trunk. Circulatory disorders in the liver, pancreas, stomach and duodenum are dependent on the degree of the celiac trunk narrowing. The collateral vascular bed fails to provide the complete compensation of the reduced organic blood flow. As a result, chronic ischemia of the organs persists.

Animals↗