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V P Nefedov

Publications and source records attributed to V P Nefedov.

44 records · Page 3Linked to original sources
PubMedDate not supplied

[Metabolic changes in rat liver in the recovery period after hyperthermic exposure].

The metabolic changes in rat liver were studied during a reduction period after the overheating (25 min, 42 degrees C) using the isolated organ perfusion. First six hours after the treatment were characterised by a decrease of the respiration rate, the activation of glycolysis and an exhaustion of hepatic carbohydrate resources. The development of adaptive reaction resulted in the recovery of respiration rate to 18 h. This may provide subsequent restoration of hepatic metabolism and normalisation of the organ functioning.

Animals↗
PubMedDate not supplied

[Disorder of the serotoninergic regulation of bone marrow cell proliferation under the action of a xenobiotic inducer of oxidative stress].

The work shows the results of experimental study of the characteristics of serotonin regulation of cell proliferation and programmed cell death in bone-marrow cells cultivated in diffusion chambers. It was found that the change in cell colony and cluster formation and death induced by this biogenic enzyme is disturbed by acrylamide, an inducer of oxidizing stress. Nicotinamide levels out the effect of acrylamide, which is evidence of the existence of NAD-dependent mechanisms in the serotonin-mediated regulation of hemopoiesis.

Acrylamide↗